• Detail
  • Binding
  • Network
Detail:
Vhid: HHID00011172
Virus: Hepatitis C virus(HCV)
Host Species: Homo sapiens
ncRNA Source: Host
ncRNA Category: miRNA
ncRNA Symbol: hsa-mir-122
Tissue: Huh-7
Expression Direction of ncRNA: Downregulation
Interactor in Virus or Host: Host
Interactor Category: Protein
Interactor Symbol: HO-1
Expression Direction of Interactor: Upregulation
Validated Method: Quantitative RT-PCR, Statistical analyses, Western Blot.
PMID: 17919492
Detailed Description: Down-regulation of HCV replication using an antagomir targeted to miR-122 is effective, specific, and selective. Increasing HO-1, by silencing the Bach1 gene or by treatment with cobalt protoporphyrin or heme, decreases HCV replication. Thus, miR-122 plays an important role in the regulation of HCV replication and HO-1/Bach1 expression in hepatocytes. Down-regulation of miR-122 and up-regulation of HO-1 may be new strategies for anti-HCV intervention and cytoprotection.
Select the transcript of gene HO-1 interacted with hsa-mir-122
The ncRNA Symbol: hsa-mir-122 Transcript of HO-1:
Visualization:
Select the center nodes: First Node Second Node Both the Nodes
Select the Level of Neighbour: First Neighbour Second Neighbour
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The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node, the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node, the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node. Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.

The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.