The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | HHID00011169 |
---|---|
Virus: | Hepatitis C virus(HCV) |
Host Species: | Homo sapiens |
ncRNA Source: | Host |
ncRNA Category: | miRNA |
ncRNA Symbol: | hsa-miR-193b |
Tissue: | Hep-394 cells |
Expression Direction of ncRNA: | Upregulation |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | Mcl-1 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Predicted. |
PMID: | 20103677 |
Detailed Description: | Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes.Of these, miR-193b was over-expressed by 5-fold in Hep-394 cells. miR-193b was predicted to target Mcl-1, an anti-apoptotic protein that can modulate the response to sorafenib. The expression of Mcl-1 expression was decreased and basal caspase-3/7 activity and PARP cleavage were increased in Hep-394 cells compared to controls. Moreover, transfection with precursors to miR-193b decreased both Mcl-1 expression and the IC50 to sorafenib. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.