The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011166 |
|---|---|
| Virus: | Hepatitis C virus(HCV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | has-mir-141 |
| Tissue: | Primary Hepatocyte Coculture |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | DLC1 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | RNA Isolation, Array-Based Klenow Enzyme Assay, Statistical Analysis and Reproducibility., Luciferase Reporter Assay, western Blot Analysis of DLC-1 Protein, fluorescein Isothiocyanate, miRNA Detection by Way of RNA-Primed, and Quan-titative PCR, Reverse-Transcription. |
| PMID: | 20967756 |
| Detailed Description: | MicroRNA miR-141 that targets DLC-1 was accentuated in cells infected with HCV genotypes 1a, 1b, and 2a. We present several lines of evidence that efficient HCV replication requires miR-141-mediated suppression of DLC-1. An increase in miR-141 correlated with the inhibition of DLC-1 protein in HCV-infected cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.