The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011141 |
|---|---|
| Virus: | Hepatitis B virus(HBV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-216a |
| Tissue: | Liver cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | CADM1 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Chromatin immunoprecipitation (ChIP), Pri-miR-216a 5'-Promoter Region Driven Luciferase Reporter Constructs, 5'RACE Analysis. |
| PMID: | 22392644 |
| Detailed Description: | we demonstrated that pri-miR-216a is activated transcriptionally by the androgen pathway in a ligand-dependent manner and is further enhanced by the hepatitis B virus X protein. One target of miR-216a was shown to be the tumor suppressor in lung cancer-1 gene(TSLC1) messenger RNA(mRNA) through the three target sites at its 3' untranslated region. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.