The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011106 |
|---|---|
| Virus: | Hepatitis B virus(HBV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-1-1 |
| Tissue: | Hepatoma cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | E2F5 |
| Expression Direction of Interactor: | Upregulation |
| Validated Method: | Western Blot Analysis, Microarray Analysis, Real-Time RT-PCR Assay, Vector Construction and Luciferase Reporter Assay, Cell Proliferation and Cell Cycle Analysis, Statistical Analysis. |
| PMID: | 21520166 |
| Detailed Description: | It was noted that microRNA-1 (miR-1) transfection resulted in a marked increase of HBV replication, accompanied with up-regulated HBV transcription, antigen expression, and progeny secretion. However, bioinformatics and luciferase reporter analysis suggested that miR-1 may not target the HBV genome directly but regulate the expression of host genes to enhance HBV replication. Further studies showed that miR-1 was able to enhance the HBV core promoter transcription activity by augmenting farnesoid X receptor alpha expression. In addition, miR-1 arrested the cell cycle at the G(1) phase and inhibited cell proliferation by targeting histone deacetylase 4 and E2F transcription factor 5. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.