The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011104 |
|---|---|
| Virus: | Hepatitis B virus(HBV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-miR-199a-5p |
| Tissue: | HCC and adjacent non-tumor tissues |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | CLTC |
| Expression Direction of Interactor: | Upregulation |
| Validated Method: | Western blotting and luciferase assay. |
| PMID: | 23082062 |
| Detailed Description: | Identification of deregulated miRNAs and their targets in hepatitis B virus-associated hepatocellular carcinoma. MiR-519a and ribosomal protein S6 kinase polypeptide 3(RPS6KA3) were predicted as the most significant candidates by miRNA-mRNA network. In addition, cyclin D3(CCND3) and clathrin heavy chain(CHC), usually up-regulated in HCC tissues, were validated as the direct target of miR-138 and miR-199a-5p, respectively. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.