The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | HHID00011093 |
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Virus: | Hendra virus |
Host Species: | Homo sapiens |
ncRNA Source: | Host |
ncRNA Category: | miRNA |
ncRNA Symbol: | hsa-mir-146a |
Tissue: | Blood |
Expression Direction of ncRNA: | Upregulation |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | RNF11 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | - |
PMID: | 23345523 |
Detailed Description: | In this work, we demonstrate that Hendra virus makes use of a microRNA (miRNA) designated miR-146a, an NFKB-responsive miRNA upregulated by several innate immune ligands, to favor its replicationIn silico analysis of miR-146a targets identified ring finger protein(RNF)11, a member of the A20 ubiquitin editing complex that negatively regulates NFKB activity, as a novel component of Hendra virus replication;silencing of RNF11 promotes Hendra virus replication in vitro. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.