The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011063 |
|---|---|
| Virus: | Enterovirus 71(EV71) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-548 |
| Tissue: | HepG2 cells |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | IFN-lambda1 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Cell culture, transfection, and detection of IFN-λ1 protein,Construction of 3′UTR reporter plasmid and luciferase reporter assay,Reverse transcription reaction and quantitative real-time PCR,Viruses and measurement of viral replication and expression,mRNA decay assay,In vitro cytotoxicity assays. |
| PMID: | 23150165 |
| Detailed Description: | miRNA-548 mimics promoted infection by enteroVirus-71 (EV71) and vesicular stomatitis Virus (VSV), whereas their inhibitors significantly suppressed the replication of EV71 and VSV. Endogenous miRNA-548 levels were suppressed during viral infection. In conclusion, our results suggest that miRNA-548 regulates host antiviral response via direct targeting of IFN-lambda1, which may offer a potential candidate for antiviral therapy. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.