The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011042 |
|---|---|
| Virus: | Coxsackievirus B3(CVB3) |
| Host Species: | Mus musculus |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | mmu-mir-21a |
| Tissue: | Cardiovascular |
| Expression Direction of ncRNA: | Downregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | PDCD4 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Real-time PCR. |
| PMID: | 23544605 |
| Detailed Description: | Further study showed that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4(PDCD4) expression.Myocardial microRNA expression changes in CVB3-infected mice were analyzed by real-time PCR and miR-21 was found to be the miRNA whose expression was significantly reduced. miR-21 administration efficiently alleviated CVB3-induced myocarditis by repressing PDCD4-mediated apoptosis. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.