The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | HHID00011030 |
|---|---|
| Virus: | Andes hantavirus(ANDV) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Host |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsa-mir-126 |
| Tissue: | Endothelial cells |
| Expression Direction of ncRNA: | Upregulation |
| Interactor in Virus or Host: | Host |
| Interactor Category: | Protein |
| Interactor Symbol: | SPRED1 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Immunoperoxidase staining of hantavirus-infected cells, cDNA synthesis, EC permeability assay, siRNA transfection, Western blot analysis, RT-PCR arrays, miRNA array real-time PCR, qRT-PCR of cellular mRNAs, MicroRNA and total RNA purification. |
| PMID: | 20844033 |
| Detailed Description: | We further analyzed changes in miR-126, an EC-specific miRNA that regulates vascular integrity by suppressing SPRED1 and PIK3R2 mRNAs.The level of miR-126, which has a known function in regulating vascular permeability, increased approximately 2-fold following ANDV infection. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.