The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VVID00011023 |
|---|---|
| Virus: | Simian virus 40(SV40) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Virus |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | sv40-miR-S1-5p |
| Tissue: | HeLa cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | SV40gp6 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Fluorescence reporter assays. |
| PMID: | 22558366 |
| Detailed Description: | Using the new reporter system, it was found that sv40-mir-S1-5p and hsa-miR423-5p downregulate the expression of common artificial target mRNAs and some predicted biological targets of hsa-miR423-5p, demonstrating that they are functional orthologs.These results demonstrated that SV40-encoded miRNA miR-S1-5p should act as a functional ortholog of the human-derived miRNA miR423-5p. SV40-encoded miR-S1-5p was reported to downregulate the expression of viral T antigen without reducing the yield of infectious virus,thus reducing host cytotoxic T lymphocyte (CTL) susceptibility and local cytokine release. . |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.