The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VVID00010980 |
|---|---|
| Virus: | Human immunodeficiency virus 1(HIV-1) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Virus |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hiv1-mir-TAR-3p |
| Tissue: | - |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | tat |
| Expression Direction of Interactor: | - |
| Validated Method: | Electrophoretic mobility shift assay, Cell culture and luciferase activity assays, Northern blot analyses, RNase protection assays, Production of virus stocks and infection, Primer extension experiments, In vitro Dicer RNase assays. |
| PMID: | 18299284 |
| Detailed Description: | HIV-1 TAR element is the target of the viral transactivating Tat protein, which is expressed during the course of HIV-1 infection and known to act at the RNA level to enhance viral gene expression by >100-fold (29). We thus examined whether Tat could shield TAR RNA and prevent its processing by Dicer. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.