The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VVID00010925 |
|---|---|
| Virus: | Herpes simplex virus 1(HSV-1) |
| Host Species: | Homo sapiens |
| ncRNA Source: | Virus |
| ncRNA Category: | miRNA |
| ncRNA Symbol: | hsv1-mir-H4 |
| Tissue: | neuronal cells |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | mRNA |
| Interactor Symbol: | ICP34.5 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Luciferase assays. |
| PMID: | 23536669 |
| Detailed Description: | Analysis of mRNA and protein expression, as well as assays mapping viral miRNA binding sites in infected cells, showed that endogenous HSV-1 miR-H2 binds to viral ICP0 mRNA and inhibits its expression,while endogenous miR-H4 inhibits the expression of the viral ICP34.5 gene. In contrast, no viral mRNA target for miR-H3 could be detected, even though miR-H3, like miR-H4, is perfectly complementary to ICP34.5 mRNA. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.