The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | VVID00010921 |
---|---|
Virus: | Herpes simplex virus 1(HSV-1) |
Host Species: | Homo sapiens |
ncRNA Source: | Virus |
ncRNA Category: | miRNA |
ncRNA Symbol: | hsv1-mir-H2 |
Tissue: | neuronal cells |
Expression Direction of ncRNA: | - |
Interactor in Virus or Host: | Virus |
Interactor Category: | mRNA |
Interactor Symbol: | ICP0 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Luciferase assays. |
PMID: | 23536669 |
Detailed Description: | Analysis of mRNA and protein expression, as well as assays mapping viral miRNA binding sites in infected cells, showed that endogenous HSV-1 miR-H2 binds to viral ICP0 mRNA and inhibits its expression,while endogenous miR-H4 inhibits the expression of the viral ICP34.5 gene. In contrast, no viral mRNA target for miR-H3 could be detected, even though miR-H3, like miR-H4, is perfectly complementary to ICP34.5 mRNA. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.