The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
| Detail: | |
| Vhid: | VVID00010916 |
|---|---|
| Virus: | Hepatitis B virus(HBV) |
| Host Species: | Mus musculus |
| ncRNA Source: | Virus |
| ncRNA Category: | ShRNA |
| ncRNA Symbol: | U6 shRNA 6 |
| Tissue: | - |
| Expression Direction of ncRNA: | - |
| Interactor in Virus or Host: | Virus |
| Interactor Category: | Protein |
| Interactor Symbol: | HBVgp3 |
| Expression Direction of Interactor: | Downregulation |
| Validated Method: | Northern blot hybridization, Expression and processing of shRNA, shRNA expression cassettes and synthetic siRNA, Assessment of in vivo efficacy of anti-HBV shRNA constructs, Quantitative PCR, Statistical analysis. |
| PMID: | 16337206 |
| Detailed Description: | Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs. Two shRNAs (shRNA 5 and shRNA 6) showed knockdown of HBV markers by 80-100% in transfected hepatocytes and also in a murine hydrodynamic injection model of HBV replication. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.