The Detail page: representing the detail information for virus-host related ncRNA interaction;
The Binding page: representing the predicted binding sites.
The Network page: representing the interaction sub-network of interacting ncRNA/Interactor.
- Detail
- Binding
- Network
Detail: | |
Vhid: | VHID00010835 |
---|---|
Virus: | Kaposi's sarcoma-associated herpesvirus(KSHV) |
Host Species: | Mus musculus |
ncRNA Source: | Virus |
ncRNA Category: | miRNA |
ncRNA Symbol: | kshv-mir-K12-11 |
Tissue: | B cells |
Expression Direction of ncRNA: | - |
Interactor in Virus or Host: | Host |
Interactor Category: | Protein |
Interactor Symbol: | Jarid2 |
Expression Direction of Interactor: | Downregulation |
Validated Method: | Luciferase reporter assay, Western blot analysis. |
PMID: | 23185331 |
Detailed Description: | We demonstrate that retroviral-mediated gene transfer and hematopoietic progenitor cell transplantation into C57BL/6 mice leads to increased B-cell fractions in lymphoid organs, as well as to enhanced germinal center formation in both microRNA-expressing mouse cohorts. We furthermore identify Jarid2, a component of Polycomb repressive complex 2, as a novel validated target of miR-K12-11, and confirm its downregulation in miR-K12-11 as well as miR-155 expressing bone marrow cells. |
The 'First Node' or 'Second Node' option represents the sub-network of interacting ncRNA/Interactor with the first or second interaction node,
the 'Both the Nodes' option represents the sub-network of interacting ncRNA/Interactor with both of interaction nodes.
The 'First Neighbour' represents the sub-network of direct interacting with the center node,
the 'Second Neighbour' represents the sub-network of direct or second step interacting with the center node.
Interaction sub-network based on the two nodes of this interaction may help the researchers represents all interacting partners immediately.