Detail Information

Basic Information:


  VIRBase ID:  

VVID00000233

  Virus:  

JC polyomavirus (Mad-1/SVE delta strain)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol jcv-miR-J1-5p Jvgp5
miRBase
Accession/Entrez ID		 MIMAT0009147 1489517
Organism JC polyomavirus (Mad-1/SVE delta strain) JC polyomavirus (Mad-1/SVE delta strain)
Category miRNA mRNA
Alias - Jvgp5

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate jcv-miR-J1-5p
Nucleus PML tissue     32324824

Interaction Network (The top 100 interactions):


Interactor1: jcv-miR-J1-5p
Interactor2: Jvgp5

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//Western blot
Support Database VmiReg

References:


PMID 18684810 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line 293 cells//U87 cells//Vero cells Interactor2 expression None
Description The reporter construct contained four iterative copies of a region of the genome encoding the JCV large TAg that is complementary to the JCV miRNAs. As expected, the cotransfection of cells with the reporter and a plasmid expressing the JCV pre-miRNA resulted in a dramatic decrease in luciferase levels, while no decrease was detected with a control reporter (lacking the JCV complementary region).

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