Detail Information

Basic Information:


  VIRBase ID:  

VVID00000213

  Virus:  

Macacine gammaherpesvirus 4

  Host:  

Macaca mulatta

  Confidence Score:  

0.9859

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol rlcv-miR-rL1-6-3p BHRF1
miRBase
Accession/Entrez ID		 MIMAT0003435 BHRF1
Organism Macacine gammaherpesvirus 4 Macacine gammaherpesvirus 4
Category miRNA mRNA
Alias - -

Interaction Network (The top 100 interactions):


Interactor1: rlcv-miR-rL1-6-3p
Interactor2: BHRF1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence PAR-CLIP//RIP-seq//Small RNA sequencing
Prediction-Evidence PARalyzer//RNAHybrid
Support Database ViRBase

References:


PMID 24257599 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells Interactor2 expression Downregulation
Description In addition to miR-BART10, we observed significant inhibition of the EBV BHRF1 3'UTR reporter in the presence of miR-BART1. miR-BART1-3p and its rLCV homolog, miR-rL1-6-3p, have seed matches (nt 2 to 8) to the EBV and rLCV BHRF1 3'UTRs, although the positions of the seed match sites and the miRNA inhibition are not conserved.

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