Basic Information: VIRBase ID: VVID00000196 Virus: Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Host: Homo sapiens Confidence Score: 0.9820 Interaction Type: Virus-Virus interaction
Interactor Information:
Interactor1
Interactor2
Symbol
kshv-miR-K12-1-5p ORF59
miRBase
MIMAT0002182 4961492
Organism
Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)
Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)
Category
miRNA
protein
Alias
-
HHV8GK18_gp70
Interaction Network (The top 100 interactions) :
Interactor1: kshv-miR-K12-1-5p
Interactor2: ORF59
Evidence Support:
Strong-Evidence
IFA//Luciferase reporter assay//qRT-PCR//Western blot
Support Database
ViRBase
References:
PMID
20081837 Target region
None
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
293T cells//BCP-1 cells
Interactor2 expression
Upregulation
Description
The miR-K1 suppressor also increased the expression of lytic protein ORF59 from 2.4% to 8.2% (3.4-fold) in uninduced PEL cells, and from 9.7% to 23% (2.4-fold) following T/B induction (Fig. 4k, l).
