Detail Information

Basic Information:


  VIRBase ID:  

VVID00000192

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9948

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART22 LMP-2A
miRBase
Accession/Entrez ID		 MIMAT0010132 3783751
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)
Category miRNA mRNA
Alias - HHV4_LMP-2A

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART22
Interactor2: LMP-2A

Evidence Support:


Strong-Evidence IFA//Luciferase reporter assay//Northern blot//RT-PCR//Western blot
Prediction-Evidence miRanda//RNAHybrid
Support Database ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 19881953 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line 293FT cells//HEK293 cells? Interactor2 expression Downregulation
Description LMP2A is a potent immunogenic viral antigen that is recognized by the cytotoxic T cells; down-modulation of LMP2A expression by miR-BART22 may permit escape of EBV-infected cells from host immune surveillance.
[2]PMID 23342366 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293FT cells//HEK293 cells? Interactor2 expression Downregulation
Description EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes.

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