Detail Information

Basic Information:


  VIRBase ID:  

VVID00000188

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-5p LMP-1
miRBase
Accession/Entrez ID		 MIMAT0003719 3783750
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)
Category miRNA mRNA
Alias - HHV4_LMP-1

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-5p
Interactor2: LMP-1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//qRT-PCR//Western blot
Support Database ViRBase

References:


PMID 24257599 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293T cells//Akata-LCLd3 cells//IBL1-LCLd3 cells Interactor2 expression None
Description Using luciferase reporter assays and by performing PAR-CLIP analysis of LCLs latently infected with EBV or rLCV, we show here that five EBV BART miRNAs (miR-BART3, miR-BART5, miR-BART16, miRBART17, and miR-BART20) and at least four rLCV BART miRNA homologs (miR-rL1-5, miR-rL1-8, miR-rL1-16, and miR-rL1-23) target LMP1 3'UTRs.

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