Detail Information

Basic Information:


  VIRBase ID:  

VVID00000186

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART20-5p BRLF1
miRBase
Accession/Entrez ID		 MIMAT0003719 3783727
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)
Category miRNA mRNA
Alias - HHV4_BRLF1

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART20-5p
Interactor2: BRLF1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Support Database ViRBase

References:


PMID 24899173 Target region 3'UTR
Source ViRBase Interactor1 expression Downregulation
Tissue or cell line AGS cells//SNU-719 cells//YCCEL1 cells Interactor2 expression Upregulation
Description As expected from the fact that the entire 3'UTR of BZLF1 resides within the 3'UTR of BRLF1, miR-BART20-5p interacted with the 3'UTR of BZLF1 as well. BZLF1 and BRLF1 mRNA and protein expression was suppressed in cells of an AGS cell line infected with the recombinant Akata strain of EBV (AGS-EBV) transfected with a miR-BART20-5p mimic.

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