Detail Information

Basic Information:


  VIRBase ID:  

VVID00000183

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9948

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART17-5p LMP-1
miRBase
Accession/Entrez ID		 MIMAT0003715 3783750
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)
Category miRNA mRNA
Alias - HHV4_LMP-1

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART17-5p
Interactor2: LMP-1

Evidence Support:


Strong-Evidence IHC//ISH//Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence MicroInspector//miRanda
Support Database ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 17911266 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line C666-1 cells//HeLa cells Interactor2 expression Downregulation
Description Here, we report that EBV-encoded BART miRNAs target the 3'UTR of the LMP1 gene and negatively regulate LMP1 protein expression. These miRNAs also modulate LMP1-induced NF-kaapaB signaling and alleviate the cisplatin sensitivity of LMP1-expressing NPC cells
[2]PMID 20580307 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line C666-1 cells//HeLa cells Interactor2 expression Downregulation
Description Lo and colleagues showed that three EBV miRNAs (miR-BART16, miR-BART17-5p, and miR-BART1-5p) target and downregulate LMP1 expression, thereby attenuating the pro-apoptotic affect of LMP1 and its inhibitory effect on NFkaapa-B. Thus, it appears that EBV miRNAs fine tune LMP1 expression in order to ensure cell survival.
[3]PMID 20719877 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line C666-1 cells//HeLa cells Interactor2 expression Downregulation
Description In some cases, the target viral mRNA is regulated by multiple miRNAs. Several of the EBV BART miRNAs from a single genomic cluster(BART1-5p, BART3-5p, BART16, and BART17-5p) work together to down-regulate production of the EBV latency membrane protein 1(LMP1).
[4]PMID 21277611 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line C666-1 cells//HeLa cells Interactor2 expression Downregulation
Description An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.

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