Detail Information

Basic Information:


  VIRBase ID:  

VVID00000176

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9612

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART6-3p EBNA-2
miRBase
Accession/Entrez ID		 MIMAT0003415 3783761
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)
Category miRNA mRNA
Alias - HHV4_EBNA-2

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART6-3p
Interactor2: EBNA-2

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//Western blot
Prediction-Evidence DIANA-microT
Support Database ViRBase

References:


PMID 20716523 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line C666-1 cells//Mutu I cells//Mutu III cells Interactor2 expression Downregulation
Description We found that miR-BART6-5p RNAs suppress the EBNA2 viral oncogene required for transition from immunologically less responsive type I and type II latency to the more immunoreactive type III latency as well as Zta and Rta viral proteins essential for lytic replication, revealing the regulatory function of miR-BART6 in EBV infection and latency.

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