Basic Information: VIRBase ID: VVID00000158 Virus: Human betaherpesvirus 5 (HHV-5) Host: Homo sapiens Confidence Score: 0.9612 Interaction Type: Virus-Virus interaction
Interactor Information:
Interactor1
Interactor2
Symbol
hcmv-miR-UL112-3p UL121
miRBase
MIMAT0001577 3077529
Organism
Human betaherpesvirus 5 (HHV-5)
Human betaherpesvirus 5 (HHV-5)
Category
miRNA
mRNA
Alias
-
HHV5wtgp106
Interaction Network (The top 100 interactions) :
Interactor1: hcmv-miR-UL112-3p
Interactor2: UL121
Evidence Support:
Strong-Evidence
Luciferase reporter assay//RT-PCR//Western blot
Prediction-Evidence
RNAHybrid
Support Database
ViRBase//VIRmiRNA//VmiReg
References:
PMID
17983268 Target region
3'UTR
Source
ViRBase//VIRmiRNA//VmiReg
Interactor1 expression
None
Tissue or cell line
293T cells//U373 cells
Interactor2 expression
Downregulation
Description
The potential target sites were screened using luciferase reporters that contain the HCMV 3'UTRs in co-transfection assays with miR-UL112-1. Three of the 14 HCMV miRNA targets were validated, including the major immediate early gene encoding IE72 (UL123, IE1), UL112/113, and UL120/121.
