Detail Information

Basic Information:


  VIRBase ID:  

VVID00000151

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsv2-miR-H4-3p RS1
miRBase
Accession/Entrez ID		 MIMAT0010204 1487291
Organism Human alphaherpesvirus 2 (HSV2) Human alphaherpesvirus 2 (HSV2)
Category miRNA mRNA
Alias - HHV2p15

Interaction Network (The top 100 interactions):


Interactor1: hsv2-miR-H4-3p
Interactor2: RS1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay//Northern blot//qPCR
Support Database ViRBase

References:


PMID 19019961 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells//HeLa cells//U2OS cells//Vero cells Interactor2 expression Downregulation
Description We used Northern hybridization to test whether destruction of the ORF-O, P ICP4-binding site affects LAT-encoded miRNA expression. R4530 expresses more miR-LAT-ICP34.5 (miR-H4-3p) than R4531 (its rescuant virus) in both Vero and SK-N-SH cells (Fig.3C), suggesting that ICP4 is involved in the regulation of miR-LAT-ICP34.5 (miR-H4-3p) expression in infected cells.

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