Detail Information

Basic Information:


  VIRBase ID:  

VVID00000150

  Virus:  

Human alphaherpesvirus 2 (HSV2)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsv2-miR-H4-5p RL1
miRBase
Accession/Entrez ID		 MIMAT0010203 1487287
Organism Human alphaherpesvirus 2 (HSV2) Human alphaherpesvirus 2 (HSV2)
Category miRNA mRNA
Alias - HHV2p16

Interaction Network (The top 100 interactions):


Interactor1: hsv2-miR-H4-5p
Interactor2: RL1

Evidence Support:


Strong-Evidence 5'-RACE//Dual luciferase reporter assay//Northern blot//qPCR
Support Database VmiReg

References:


PMID 19019961 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line U2OS cells Interactor2 expression Downregulation
Description We further show that, similar to miR-I, miR-II is able to efficiently silence the expression of ICP34.5, a key viral neurovirulence factor, and that miR-III is able to silence the expression of ICP0, a key viral transactivator. All these data suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded miRNAs and their viral targets.

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