MiR-H6 shows extended seed complementarity to the mRNA encoding a second HSV-1 transcription factor, ICP4[RS1], and inhibits expression of ICP4[RS1], which is required for expression of most HSV-1 genes during productive infection4.
From the targets identified to date (Table 1, Figure 1) it is apparent that viral miRNAs play an important role in immune evasion by inhibiting immune surveillance and extending the life of the infected host cell. Table 1 Immunomodulatory viral miRNAs.
An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.
