Detail Information

Basic Information:


  VIRBase ID:  

VVID00000143

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9923

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsv1-miR-H4-3p RL1
miRBase
Accession/Entrez ID		 MIMAT0008402 2703395
Organism Human alphaherpesvirus 1 (HSV-1) Human alphaherpesvirus 1 (HSV-1)
Category miRNA mRNA
Alias - HHV1gp00p77

Interaction Network (The top 100 interactions):


Interactor1: hsv1-miR-H4-3p
Interactor2: RL1

Evidence Support:


Strong-Evidence Luciferase reporter assay//qRT-PCR//RT-PCR//Western blot
Weak-Evidence PAR-CLIP//RIP-seq
Support Database ViRBase//VmiReg

References:


PMID 23536669 Target region 5'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line 293T cells//SY5Y cells Interactor2 expression Downregulation
Description Analysis of mRNA and protein expression, as well as assays mapping viral miRNA binding sites in infected cells, showed that endogenous HSV-1 miR-H2 binds to viral ICP0 mRNA and inhibits its expression,while endogenous miR-H4 inhibits the expression of the viral ICP34.5 gene. In contrast, no viral mRNA target for miR-H3 could be detected, even though miR-H3, like miR-H4, is perfectly complementary to ICP34.5 mRNA.

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