Detail Information

Basic Information:


  VIRBase ID:  

VVID00000140

  Virus:  

Human alphaherpesvirus 1 (HSV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9820

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsv1-miR-H2-3p RL1
miRBase
Accession/Entrez ID		 MIMAT0008399 2703395
Organism Human alphaherpesvirus 1 (HSV-1) Human alphaherpesvirus 1 (HSV-1)
Category miRNA mRNA
Alias - HHV1gp00p77

Interaction Network (The top 100 interactions):


Interactor1: hsv1-miR-H2-3p
Interactor2: RL1

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//qPCR//TaqMan qPCR
Support Database ViRBase

References:


[1]PMID 18678906 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells//U2OS cells Interactor2 expression Downregulation
Description The presence of HSV-1 miR-LAT-ICP34.5 indicates that miRNAs encoded by HSV-1 and HSV-2 LATs are evolutionarily conserved in their locations rather than in their sequences, implying that the mechanism by which LAT functions in trans as miRNAs in regulating ICP34.5 expression is shared in HSV-1 and HSV-2.
[2]PMID 21277611 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line 293 cells//U2OS cells Interactor2 expression Downregulation
Description An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.

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