Detail Information

Basic Information:


  VIRBase ID:  

VVID00000054

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9526

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol mdv1-miR-M7-5p MDV084
miRBase
Accession/Entrez ID		 MIMAT0005804 4811547
Organism Gallid alphaherpesvirus 2 Gallid alphaherpesvirus 2
Category miRNA mRNA
Alias - GaHV2Md5_gp083//MD5V_084

Interaction Network (The top 100 interactions):


Interactor1: mdv1-miR-M7-5p
Interactor2: MDV084

Evidence Support:


Strong-Evidence IFA//Luciferase reporter assay//RACE
Support Database VmiReg

References:


PMID 22513387 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line MSB1 cells Interactor2 expression None
Description We identified MDV immediate-early (IE) genes ICP4 and ICP27 as putative targets of mdv1-miR-M7-5p, the third microRNA of the cluster mdv1-miR-M8-M10. Endogenously expressed mdv1-miR-M7-5p in MSB-1 cells reduced luciferase activity significantly when microRNA-responsive elements from ICP4 or ICP27 were cloned in the 3' UTR of the firefly luciferase gene.

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