Detail Information

Basic Information:


  VIRBase ID:  

VVID00000030

  Virus:  

Gallid alphaherpesvirus 2

  Host:  

Gallus gallus

  Confidence Score:  

0.9806

  Interaction Type:  

Virus-Virus interaction

Interactor Information:


Interactor1 Interactor2
Symbol mdv1-miR-M4-5p MDV046
miRBase
Accession/Entrez ID		 MIMAT0003924 4811506
Organism Gallid alphaherpesvirus 2 Gallid alphaherpesvirus 2
Category miRNA mRNA
Alias - GaHV2Md5_gp045//MD5V_046

Interaction Network (The top 100 interactions):


Interactor1: mdv1-miR-M4-5p
Interactor2: MDV046

Evidence Support:


Strong-Evidence Luciferase reporter assay//Northern blot//Western blot
Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer//Targetscan
Support Database ViRBase//VmiReg

References:


[1]PMID 20680360 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line DF-1 cells//DT-40 cells//LMH cells//MDCC-54-O cells//MDCC-MSB-1 cells Interactor2 expression Downregulation
Description Thus, mdv1-pre-miR-M4 efficiently inhibits the production of the UL28 and UL32 proteins, whereas gga-pre-miR-155 does not.
[2]PMID 21277611 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line DF-1 cells//MDCC-54-O cells//MDCC-MSB-1 cells Interactor2 expression Downregulation
Description An overview of known targets of cellular or viral targets is given in tables 2 and 3.Table 2 Cellular Targets of viral miRNAs.Table 3 Viral Targets of viral miRNAs.
[3]PMID 24449754 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line MSB1 cells Interactor2 expression None
Description A list of all RISC binding clusters identified, with their predicted miRNAs, is given in Table S1 in the supplemental material. Of these 16,585 binding clusters, PARalyzer predicted 1, 104 cellular mRNAs that were bound by one or more MDV-1 miRNAs, while 1, 183 cellular mRNAs were predicted to be bound by one or more MDV-2 miRNAs.

Starting a new search, please wait ...