Detail Information

Basic Information:


  VIRBase ID:  

VHID00706637

  Virus:  

SARS-CoV-2 (NC_045512.2)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol sars-cov-2-mir-D10-5p SMAD4
miRBase
Accession/Entrez ID		 sars-cov-2-mir-D10-5p 4089
Organism SARS-CoV-2 (NC_045512.2) Homo sapiens
Category miRNA mRNA
Alias - DPC4//JIP//MADH4//MYHRS

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SMAD4
chr18:48578306(+) A-I      intronic
chr18:48578316(+) A-I      intronic
chr18:48600534(+) A-I      intronic
chr18:48565383(+) A-I      intronic
chr18:48600546(+) A-I      intronic
chr18:48565420(+) A-I      intronic
chr18:48565430(+) A-I      intronic
chr18:48600660(+) A-I      intronic
chr18:48600620(+) A-I      intronic
chr18:48600584(+) A-I      intronic
chr18:48600566(+) A-I      intronic
chr18:48600515(+) A-I      intronic
chr18:48600494(+) A-I      intronic
chr18:48600161(+) A-I      intronic
chr18:48600119(+) A-I      intronic
chr18:48600067(+) A-I      intronic
chr18:48570615(+) A-I      intronic
chr18:48565362(+) A-I      intronic
chr18:48600066(+) A-I      intronic
chr18:48595694(+) A-I      intronic
chr18:48595551(+) A-I      intronic
chr18:48595530(+) A-I      intronic
chr18:48570618(+) A-I      intronic
chr18:48593847(+) A-I      intronic
chr18:48595195(+) A-I      intronic
chr18:48595225(+) A-I      intronic
chr18:48595093(+) A-I      intronic
chr18:48562405(+) A-I      intronic
chr18:48595535(+) A-I      intronic
chr18:48568917(+) A-I      intronic
chr18:48595180(+) A-I      intronic
chr18:48563434(+) A-I      intronic
chr18:48595170(+) A-I      intronic
chr18:48600703(+) A-I      intronic
chr18:48600081(+) A-I      intronic
chr18:48595087(+) A-I      intronic
chr18:48562381(+) A-I      intronic
chr18:48570614(+) A-I      intronic
chr18:48595746(+) A-I      intronic
chr18:48600630(+) A-I      intronic
chr18:48595261(+) A-I      intronic
chr18:48600580(+) A-I      intronic
chr18:48595737(+) A-I      intronic
chr18:48600601(+) A-I      intronic
chr18:48595733(+) A-I      intronic
chr18:48600486(+) A-I      intronic
chr18:48565357(+) A-I      intronic
chr18:48607095(+) A-I      3'UTR
chr18:48593963(+) A-I      intronic
chr18:48600587(+) A-I      intronic
chr18:48568940(+) A-I      intronic
chr18:48568907(+) A-I      intronic
chr18:48595141(+) A-I      intronic
chr18:48595616(+) A-I      intronic
chr18:48563346(+) A-I      intronic
chr18:48600040(+) A-I      intronic
chr18:48600084(+) A-I      intronic
chr18:48562477(+) A-I      intronic
chr18:48568854(+) A-I      intronic
chr18:48600510(+) A-I      intronic
chr18:48561789(+) A-I      intronic
chr18:48570546(+) A-I      intronic
chr18:48563433(+) A-I      intronic
chr18:48600585(+) A-I      intronic
chr18:48595628(+) A-I      intronic
chr18:48595626(+) A-I      intronic
chr18:48600567(+) A-I      intronic
chr18:48595266(+) A-I      intronic
chr18:48595682(+) A-I      intronic
chr18:48593863(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SMAD4
chr18:48570896(+) A-I intron -    21960545
chr18:48600040(+) A-I intron -    21960545
chr18:48565356(+) A-G intron -    22484847
chr18:48565357(+) A-G intron -    22484847
chr18:48595087(+) A-G intron -    22484847
chr18:48600486(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SMAD4
chr18:48556546-48556547(+) m6A 5'UTR//intron       24981863
chr18:48573383-48573384(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573406-48573407(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573412-48573413(+) m6A 5'UTR//intron       24284625//24981863//26404942//22608085
chr18:48573420-48573421(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48573496-48573497(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48573515-48573516(+) m6A CDS//intron       24284625//24981863//26404942//22608085
chr18:48581199-48581200(+) m6A CDS//exon       -
chr18:48581223-48581224(+) m6A CDS//exon       -
chr18:48581236-48581237(+) m6A CDS//exon       -
chr18:48581275-48581276(+) m6A CDS//exon       -
chr18:48584534-48584535(+) m6A CDS//exon//intron       -
chr18:48584567-48584568(+) m6A CDS//exon//intron       -
chr18:48584726-48584727(+) m6A CDS//exon//intron       24981863
chr18:48584738-48584739(+) m6A CDS//exon//intron       24284625//24981863
chr18:48584818-48584819(+) m6A CDS//exon//intron       24284625//24981863
chr18:48591912-48591913(+) Gm CDS//exon//intron       -
chr18:48604707-48604708(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604722-48604723(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604738-48604739(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr18:48604817-48604818(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604832-48604833(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604879-48604880(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22608085
chr18:48604986-48604987(+) m6A 3'UTR//exon       24981863//22608085
chr18:48604992-48604993(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605003-48605004(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605027-48605028(+) m6A 3'UTR//exon       24981863//22608085
chr18:48605053-48605054(+) Am 3'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SMAD4
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: sars-cov-2-mir-D10-5p
Interactor2: SMAD4

Evidence Support:


Prediction-Evidence miRanda//miRDB//Targetscan
Support Database ViRBase

References:


PMID 33398248 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line None Interactor2 expression None
Description Cytotoxin and gene regulation associated genes targeted by SARS-CoV-2 encoded miRNAs.

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