Detail Information
Interactor1 | Interactor2 | |
---|---|---|
Symbol | hiv1-miR-TAR-3p | DICER1 |
miRBase Accession/Entrez ID |
MIMAT0006017 | 23405 |
Organism | Human immunodeficiency virus 1 (HIV-1) | Homo sapiens |
Category | miRNA | protein |
Alias | - | DCR1//Dicer//Dicer1e//GLOW//HERNA//K12H4.8-LIKE//MNG1//RMSE2 |
Resource | Symbol | Editing Position | Change | Genetic Region | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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RADAR | DICER1 |
|
Resource | Symbol | Editing Position | Change | SeqReg | exReg | PMID |
---|---|---|---|---|---|---|
DARNED | DICER1 |
Resource | Symbol | ModificationPosition | Type | Genomic Context | PMID | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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RMBase | DICER1 |
|
Resource | Symbol | Subcellular Localization | Tissue or Cell Line | PMID | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RNALocate | DICER1 |
|
Resource | Symbol | Drug Name | PubChem ID |
---|---|---|---|
RNAactDrug | hiv1-miR-TAR-3p |
Interactor1: hiv1-miR-TAR-3p | Interactor2: DICER1 |
---|
Strong-Evidence | Luciferase reporter assay//Pull down assay//RPA//Western blot | |
---|---|---|
Support Database | ViRBase |
[1]PMID | 17663774 | Target region | None |
---|---|---|---|
Source | ViRBase | Interactor1 expression | None |
Tissue or cell line | 293 cells//ACH2 cells//BJAB cells//CEM cells | Interactor2 expression | Downregulation |
Description | This shows that Dicer, expressed in CD4+ T-cells and HIV-1 infected T-cells, binds to the HIV-1 TAR structure and implies that the TAR element present in HIV-1 infected or latently infected cells may be processed by Dicer to yield a viral miRNA. |
[2]PMID | 22936931 | Target region | None |
---|---|---|---|
Source | ViRBase | Interactor1 expression | None |
Tissue or cell line | 293 cells//ACH2 cells//BJAB cells//CEM cells | Interactor2 expression | Downregulation |
Description | Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators. |
[3]PMID | 21133815 | Target region | None |
---|---|---|---|
Source | ViRBase | Interactor1 expression | None |
Tissue or cell line | 293 cells//ACH2 cells//BJAB cells//CEM cells | Interactor2 expression | Downregulation |
Description | It has also been demonstrated by ethidium bromide staining and radioactive labeling that the TAR--Dicer association results in cleavage of the TAR RNA. |