Basic Information:

  VIRBase ID:  

VHID00703573

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.2455

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-3p:  MIMAT0006017          SIRT1:  NM_001314049     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-3p	SIRT1
miRBase Accession/Entrez ID	MIMAT0006017	23411
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SIR2//SIR2alpha//SIR2L1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SIRT1	chr10:69652499(+) A-I      intronic chr10:69652073(+) A-I      intronic chr10:69657868(+) A-I      intronic chr10:69657889(+) A-I      intronic chr10:69657902(+) A-I      intronic chr10:69657910(+) A-I      intronic chr10:69659824(+) A-I      intronic chr10:69645898(+) A-I      intronic chr10:69659826(+) A-I      intronic chr10:69660085(+) A-I      intronic chr10:69664003(+) A-I      intronic chr10:69656771(+) A-I      intronic chr10:69656738(+) A-I      intronic chr10:69656694(+) A-I      intronic chr10:69656402(+) A-I      intronic chr10:69656395(+) A-I      intronic chr10:69661020(+) A-I      intronic chr10:69655106(+) A-I      intronic chr10:69656394(+) A-I      intronic chr10:69656189(+) A-I      intronic chr10:69656184(+) A-I      intronic chr10:69656182(+) A-I      intronic chr10:69670044(+) A-I      intronic chr10:69656178(+) A-I      intronic chr10:69655680(+) A-I      intronic chr10:69655604(+) A-I      intronic chr10:69655603(+) A-I      intronic chr10:69655594(+) A-I      intronic chr10:69655073(+) A-I      intronic chr10:69653804(+) A-I      intronic chr10:69655065(+) A-I      intronic chr10:69655032(+) A-I      intronic chr10:69654939(+) A-I      intronic chr10:69654594(+) A-I      intronic chr10:69654567(+) A-I      intronic chr10:69660940(+) A-I      intronic chr10:69653808(+) A-I      intronic chr10:69657069(+) A-I      intronic chr10:69652460(+) A-I      intronic chr10:69652158(+) A-I      intronic chr10:69652114(+) A-I      intronic chr10:69652095(+) A-I      intronic chr10:69652074(+) A-I      intronic chr10:69650498(+) A-I      intronic chr10:69650364(+) A-I      intronic chr10:69657324(+) A-I      intronic chr10:69663998(+) A-I      intronic chr10:69650283(+) A-I      intronic chr10:69659656(+) A-I      intronic chr10:69650016(+) A-I      intronic chr10:69649997(+) A-I      intronic chr10:69649971(+) A-I      intronic chr10:69649918(+) A-I      intronic chr10:69649914(+) A-I      intronic chr10:69647514(+) A-I      intronic chr10:69646302(+) A-I      intronic chr10:69646266(+) A-I      intronic chr10:69646233(+) A-I      intronic chr10:69664117(+) A-I      intronic chr10:69653383(+) A-I      intronic chr10:69657871(+) A-I      intronic chr10:69657920(+) A-I      intronic chr10:69659763(+) A-I      intronic chr10:69661032(+) A-I      intronic chr10:69657832(+) A-I      intronic chr10:69657923(+) A-I      intronic chr10:69646186(+) A-I      intronic chr10:69657896(+) A-I      intronic chr10:69657811(+) A-I      intronic chr10:69649943(+) A-I      intronic chr10:69646293(+) A-I      intronic chr10:69646795(+) A-I      intronic chr10:69650727(+) A-I      intronic chr10:69657151(+) A-I      intronic chr10:69669351(+) A-I      intronic chr10:69650677(+) A-I      intronic chr10:69655069(+) A-I      intronic chr10:69656728(+) A-I      intronic chr10:69660290(+) A-I      intronic chr10:69662953(+) A-I      intronic chr10:69657319(+) A-I      intronic chr10:69659948(+) A-I      intronic chr10:69661003(+) A-I      intronic chr10:69669461(+) A-I      intronic chr10:69664481(+) A-I      intronic chr10:69654945(+) A-I      intronic chr10:69656793(+) A-I      intronic chr10:69657840(+) A-I      intronic chr10:69671084(+) A-I      intronic chr10:69654716(+) A-I      intronic chr10:69671054(+) A-I      intronic chr10:69656680(+) A-I      intronic chr10:69654715(+) A-I      intronic chr10:69657809(+) A-I      intronic chr10:69657859(+) A-I      intronic chr10:69657841(+) A-I      intronic chr10:69657810(+) A-I      intronic chr10:69652204(+) A-I      intronic chr10:69656304(+) A-I      intronic chr10:69671038(+) A-I      intronic chr10:69656392(+) A-I      intronic chr10:69662768(+) A-I      intronic chr10:69657962(+) A-I      intronic chr10:69657945(+) A-I      intronic chr10:69671037(+) A-I      intronic chr10:69671020(+) A-I      intronic chr10:69670064(+) A-I      intronic chr10:69670021(+) A-I      intronic chr10:69654996(+) A-I      intronic chr10:69654641(+) A-I      intronic chr10:69664331(+) A-I      intronic chr10:69669882(+) A-I      intronic chr10:69664546(+) A-I      intronic chr10:69664522(+) A-I      intronic chr10:69659655(+) A-I      intronic chr10:69664516(+) A-I      intronic chr10:69664507(+) A-I      intronic chr10:69664494(+) A-I      intronic chr10:69664455(+) A-I      intronic chr10:69664427(+) A-I      intronic chr10:69664364(+) A-I      intronic chr10:69646259(+) A-I      intronic chr10:69664084(+) A-I      intronic chr10:69657977(+) A-I      intronic chr10:69664078(+) A-I      intronic chr10:69663946(+) A-I      intronic chr10:69649953(+) A-I      intronic chr10:69663401(+) A-I      intronic chr10:69660245(+) A-I      intronic chr10:69663392(+) A-I      intronic chr10:69663330(+) A-I      intronic chr10:69663269(+) A-I      intronic chr10:69663220(+) A-I      intronic chr10:69663211(+) A-I      intronic chr10:69661008(+) A-I      intronic chr10:69660936(+) A-I      intronic chr10:69657219(+) A-I      intronic chr10:69660150(+) A-I      intronic chr10:69660004(+) A-I      intronic chr10:69657937(+) A-I      intronic chr10:69660003(+) A-I      intronic chr10:69659754(+) A-I      intronic chr10:69654585(+) A-I      intronic chr10:69657942(+) A-I      intronic chr10:69659664(+) A-I      intronic chr10:69659654(+) A-I      intronic chr10:69658042(+) A-I      intronic chr10:69657929(+) A-I      intronic chr10:69657867(+) A-I      intronic chr10:69657441(+) A-I      intronic chr10:69657305(+) A-I      intronic chr10:69657302(+) A-I      intronic chr10:69657288(+) A-I      intronic chr10:69656835(+) A-I      intronic chr10:69657240(+) A-I      intronic chr10:69657252(+) A-I      intronic chr10:69669885(+) A-I      intronic chr10:69657264(+) A-I      intronic chr10:69656794(+) A-I      intronic chr10:69660038(+) A-I      intronic chr10:69654572(+) A-I      intronic chr10:69658473(+) A-I      intronic chr10:69659837(+) A-I      intronic chr10:69653777(+) A-I      intronic chr10:69646227(+) A-I      intronic chr10:69660137(+) A-I      intronic chr10:69656406(+) A-I      intronic chr10:69663352(+) A-I      intronic chr10:69657436(+) A-I      intronic chr10:69660259(+) A-I      intronic chr10:69670011(+) A-I      intronic chr10:69669970(+) A-I      intronic chr10:69653468(+) A-I      intronic chr10:69662597(+) A-I      intronic chr10:69653778(+) A-I      intronic chr10:69657439(+) A-I      intronic chr10:69657150(+) A-I      intronic chr10:69664185(+) A-I      intronic chr10:69654706(+) A-I      intronic chr10:69649979(+) A-I      intronic chr10:69650550(+) A-I      intronic chr10:69664402(+) A-I      intronic chr10:69652382(+) A-I      intronic chr10:69669976(+) A-I      intronic chr10:69655093(+) A-I      intronic chr10:69646165(+) A-I      intronic chr10:69660165(+) A-I      intronic chr10:69650086(+) A-I      intronic chr10:69657262(+) A-I      intronic chr10:69649940(+) A-I      intronic chr10:69664025(+) A-I      intronic chr10:69659915(+) A-I      intronic chr10:69652477(+) A-I      intronic chr10:69664052(+) A-I      intronic chr10:69657518(+) A-I      intronic chr10:69657382(+) A-I      intronic chr10:69657416(+) A-I      intronic chr10:69662728(+) A-I      intronic chr10:69649931(+) A-I      intronic chr10:69663260(+) A-I      intronic chr10:69646096(+) A-I      intronic chr10:69662667(+) A-I      intronic chr10:69669985(+) A-I      intronic chr10:69659727(+) A-I      intronic chr10:69662985(+) A-I      intronic chr10:69657932(+) A-I      intronic chr10:69660164(+) A-I      intronic chr10:69656727(+) A-I      intronic chr10:69664133(+) A-I      intronic chr10:69662722(+) A-I      intronic chr10:69650527(+) A-I      intronic chr10:69655574(+) A-I      intronic chr10:69646141(+) A-I      intronic chr10:69664348(+) A-I      intronic chr10:69646104(+) A-I      intronic chr10:69663407(+) A-I      intronic chr10:69654992(+) A-I      intronic chr10:69662666(+) A-I      intronic chr10:69650586(+) A-I      intronic chr10:69671080(+) A-I      intronic chr10:69652233(+) A-I      intronic chr10:69653764(+) A-I      intronic chr10:69662761(+) A-I      intronic chr10:69653795(+) A-I      intronic chr10:69653503(+) A-I      intronic chr10:69652543(+) A-I      intronic chr10:69654597(+) A-I      intronic chr10:69652489(+) A-I      intronic chr10:69654667(+) A-I      intronic chr10:69657842(+) A-I      intronic chr10:69659721(+) A-I      intronic chr10:69652210(+) A-I      intronic chr10:69645759(+) A-I      intronic chr10:69660065(+) A-I      intronic chr10:69650344(+) A-I      intronic chr10:69645881(+) A-I      intronic chr10:69663916(+) A-I      intronic chr10:69645830(+) A-I      intronic chr10:69646198(+) A-I      intronic chr10:69654728(+) A-I      intronic chr10:69655577(+) A-I      intronic chr10:69646169(+) A-I      intronic chr10:69656391(+) A-I      intronic chr10:69664498(+) A-I      intronic chr10:69656829(+) A-I      intronic chr10:69645884(+) A-I      intronic chr10:69654999(+) A-I      intronic chr10:69659927(+) A-I      intronic chr10:69669471(+) A-I      intronic chr10:69655109(+) A-I      intronic chr10:69656093(+) A-I      intronic chr10:69663406(+) A-I      intronic chr10:69650247(+) A-I      intronic chr10:69663985(+) A-I      intronic chr10:69661030(+) A-I      intronic chr10:69650603(+) A-I      intronic chr10:69655019(+) A-I      intronic chr10:69646095(+) A-I      intronic chr10:69657857(+) A-I      intronic chr10:69659632(+) A-I      intronic chr10:69661077(+) A-I      intronic chr10:69652147(+) A-I      intronic chr10:69653380(+) A-I      intronic chr10:69660029(+) A-I      intronic chr10:69659748(+) A-I      intronic chr10:69655082(+) A-I      intronic chr10:69646255(+) A-I      intronic chr10:69669971(+) A-I      intronic chr10:69656393(+) A-I      intronic chr10:69660303(+) A-I      intronic chr10:69656276(+) A-I      intronic chr10:69664012(+) A-I      intronic chr10:69669721(+) A-I      intronic chr10:69660045(+) A-I      intronic chr10:69656767(+) A-I      intronic chr10:69659565(+) A-I      intronic chr10:69659744(+) A-I      intronic chr10:69656400(+) A-I      intronic chr10:69659762(+) A-I      intronic chr10:69663281(+) A-I      intronic chr10:69657490(+) A-I      intronic chr10:69652501(+) A-I      intronic chr10:69649955(+) A-I      intronic chr10:69656465(+) A-I      intronic chr10:69657834(+) A-I      intronic chr10:69656103(+) A-I      intronic chr10:69662801(+) A-I      intronic chr10:69650370(+) A-I      intronic chr10:69654542(+) A-I      intronic chr10:69652241(+) A-I      intronic chr10:69654593(+) A-I      intronic chr10:69652148(+) A-I      intronic chr10:69650539(+) A-I      intronic chr10:69669737(+) A-I      intronic chr10:69654923(+) A-I      intronic chr10:69652139(+) A-I      intronic chr10:69657499(+) A-I      intronic chr10:69663344(+) A-I      intronic chr10:69664130(+) A-I      intronic chr10:69659879(+) A-I      intronic chr10:69650384(+) A-I      intronic chr10:69656445(+) A-I      intronic chr10:69659878(+) A-I      intronic chr10:69657897(+) A-I      intronic chr10:69646053(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SIRT1	chr10:69657809(+) A-I intron -    22028664 chr10:69657810(+) A-I intron -    22028664 chr10:69657811(+) A-I intron -    22028664 chr10:69657832(+) A-I intron -    22028664 chr10:69657834(+) A-I intron -    22028664 chr10:69657840(+) A-I intron -    22028664 chr10:69657841(+) A-I intron -    22028664 chr10:69657842(+) A-I intron -    22028664 chr10:69657859(+) A-I intron -    22028664 chr10:69657896(+) A-I intron -    22028664 chr10:69657897(+) A-I intron -    22028664 chr10:69657920(+) A-I intron -    22028664 chr10:69657923(+) A-I intron -    22028664 chr10:69657932(+) A-I intron -    22028664 chr10:69657937(+) A-I intron -    22028664 chr10:69657942(+) A-I intron -    22028664 chr10:69657945(+) A-I intron -    22028664 chr10:69657962(+) A-I intron -    22028664 chr10:69657977(+) A-I intron -    22028664 chr10:69652210(+) A-I intron -    21960545 chr10:69661008(+) A-I intron -    21960545 chr10:69650603(+) A-G intron -    22484847 chr10:69664117(+) A-G intron -    22484847 chr10:69664130(+) A-G intron -    22484847 chr10:69671054(+) A-G intron -    22484847 chr10:69671080(+) A-G intron -    22484847 chr10:69671084(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIRT1	chr10:69644783-69644784(+) m6A CDS       24284625//24209618//24981863//22575960 chr10:69669179-69669180(+) m6A CDS       24284625 chr10:69672273-69672274(+) m6A CDS       24284625//24981863//26404942//22608085 chr10:69672314-69672315(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672369-69672370(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672411-69672412(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672421-69672422(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672482-69672483(+) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr10:69672502-69672503(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672542-69672543(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672606-69672607(+) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr10:69672622-69672623(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr10:69672651-69672652(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr10:69672712-69672713(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69672727-69672728(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676084-69676085(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676140-69676141(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676166-69676167(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr10:69676260-69676261(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676307-69676308(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676321-69676322(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676327-69676328(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676339-69676340(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676395-69676396(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr10:69676429-69676430(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr10:69676447-69676448(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr10:69676534-69676535(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SIRT1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hiv1-miR-TAR-3p	l-685,458       5479543 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-3p
Interactor2: SIRT1

Evidence Support:

Prediction-Evidence	cRep//miRanda//PITA//Targetscan
Support Database	RepTar//VmiReg