Basic Information:

  VIRBase ID:  

VHID00703156

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9948

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-3p:  MIMAT0006017          IKZF1:  NM_001291844     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-3p	IKZF1
miRBase Accession/Entrez ID	MIMAT0006017	10320
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CVID13//Hs.54452//IK1//IKAROS//LyF-1//LYF1//PPP1R92//PRO0758//ZNFN1A1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IKZF1	chr7:50353888(+) A-I      intronic chr7:50365256(+) A-I      intronic chr7:50365275(+) A-I      intronic chr7:50426803(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IKZF1	chr7:50467699-50467700(+) m6A CDS//exon//intron       - chr7:50467864-50467865(+) m6A CDS//exon       27371828 chr7:50467879-50467880(+) m6A CDS//exon       27371828 chr7:50467951-50467952(+) m6A CDS//exon       27371828 chr7:50467960-50467961(+) m6A CDS//exon       27371828 chr7:50468095-50468096(+) m6A CDS//exon       25456834//27371828 chr7:50468159-50468160(+) m6A CDS//exon       25456834 chr7:50468266-50468267(+) m6A CDS//exon       25456834 chr7:50468349-50468350(+) m6A 3'UTR       24209618//25456834//24981863//27371828 chr7:50468379-50468380(+) m6A 3'UTR       24209618//25456834//24981863//27371828 chr7:50468412-50468413(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468417-50468418(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468422-50468423(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468427-50468428(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468550-50468551(+) m6A 3'UTR       - chr7:50468578-50468579(+) m6A 3'UTR       - chr7:50468666-50468667(+) m6A 3'UTR       - chr7:50470000-50470001(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IKZF1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hiv1-miR-TAR-3p	l-685,458       5479543 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-3p
Interactor2: IKZF1

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//IP//Northern blot//RT-PCR//Western blot
Prediction-Evidence	miRanda//PITA
Support Database	VmiReg

References:

PMID	23938024	Target region	3'UTR
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Bioinformatic predictions and reporter gene activity assays identified regulatory elements complementary and responsive to miR-TAR-5p and miR-TAR-3p in the 3' untranslated region (UTR) of several candidate genes involved in apoptosis and cell survival. These include Caspase 8, Aiolos, Ikaros and Nucleophosmin (NPM)/B23.