Basic Information:

  VIRBase ID:  

VHID00702103

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9933

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-3p:  MIMAT0006017          NPM1:  NR_149149     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-3p	NPM1
miRBase Accession/Entrez ID	MIMAT0006017	4869
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B23//NPM

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NPM1	chr5:170828282(+) A-I      intronic chr5:170828210(+) A-I      intronic chr5:170828161(+) A-I      intronic chr5:170827661(+) A-I      intronic chr5:170827635(+) A-I      intronic chr5:170827626(+) A-I      intronic chr5:170827622(+) A-I      intronic chr5:170825708(+) A-I      intronic chr5:170827618(+) A-I      intronic chr5:170827602(+) A-I      intronic chr5:170827600(+) A-I      intronic chr5:170827590(+) A-I      intronic chr5:170827587(+) A-I      intronic chr5:170821358(+) A-I      intronic chr5:170821361(+) A-I      intronic chr5:170821392(+) A-I      intronic chr5:170821406(+) A-I      intronic chr5:170821973(+) A-I      intronic chr5:170821987(+) A-I      intronic chr5:170822021(+) A-I      intronic chr5:170822030(+) A-I      intronic chr5:170822090(+) A-I      intronic chr5:170822433(+) A-I      intronic chr5:170822470(+) A-I      intronic chr5:170823735(+) A-I      intronic chr5:170823789(+) A-I      intronic chr5:170823862(+) A-I      intronic chr5:170823883(+) A-I      intronic chr5:170823897(+) A-I      intronic chr5:170823898(+) A-I      intronic chr5:170823927(+) A-I      intronic chr5:170823960(+) A-I      intronic chr5:170825617(+) A-I      intronic chr5:170825733(+) A-I      intronic chr5:170825621(+) A-I      intronic chr5:170823199(+) A-I      intronic chr5:170827597(+) A-I      intronic chr5:170825660(+) A-I      intronic chr5:170837083(+) A-I      intronic chr5:170837076(+) A-I      intronic chr5:170836449(+) A-I      intronic chr5:170836405(+) A-I      intronic chr5:170836372(+) A-I      intronic chr5:170832009(+) A-I      intronic chr5:170828680(+) A-I      intronic chr5:170828540(+) A-I      intronic chr5:170828273(+) A-I      intronic chr5:170828271(+) A-I      intronic chr5:170828268(+) A-I      intronic chr5:170828204(+) A-I      intronic chr5:170828155(+) A-I      intronic chr5:170828142(+) A-I      intronic chr5:170826503(+) A-I      intronic chr5:170826405(+) A-I      intronic chr5:170826035(+) A-I      intronic chr5:170826029(+) A-I      intronic chr5:170826007(+) A-I      intronic chr5:170825897(+) A-I      intronic chr5:170825636(+) A-I      intronic chr5:170836404(+) A-I      intronic chr5:170828283(+) A-I      intronic chr5:170823786(+) A-I      intronic chr5:170828668(+) A-I      intronic chr5:170822007(+) A-I      intronic chr5:170822024(+) A-I      intronic chr5:170828185(+) A-I      intronic chr5:170822443(+) A-I      intronic chr5:170825619(+) A-I      intronic chr5:170828567(+) A-I      intronic chr5:170820936(+) A-I      intronic chr5:170822397(+) A-I      intronic chr5:170825994(+) A-I      intronic chr5:170825524(+) A-I      intronic chr5:170822104(+) A-I      intronic chr5:170825996(+) A-I      intronic chr5:170826038(+) A-I      intronic chr5:170836785(+) A-I      intronic chr5:170826502(+) A-I      intronic chr5:170828255(+) A-I      intronic chr5:170822128(+) A-I      intronic chr5:170836477(+) A-I      intronic chr5:170821933(+) A-I      intronic chr5:170821439(+) A-I      intronic chr5:170820859(+) A-I      intronic chr5:170828206(+) A-I      intronic chr5:170836395(+) A-I      intronic chr5:170826075(+) A-I      intronic chr5:170836958(+) A-I      intronic chr5:170825984(+) A-I      intronic chr5:170828625(+) A-I      intronic chr5:170822484(+) A-I      intronic chr5:170828128(+) A-I      intronic chr5:170822487(+) A-I      intronic chr5:170836409(+) A-I      intronic chr5:170826509(+) A-I      intronic chr5:170825917(+) A-I      intronic chr5:170822133(+) A-I      intronic chr5:170836928(+) A-I      intronic chr5:170822489(+) A-I      intronic chr5:170828241(+) A-I      intronic chr5:170828675(+) A-I      intronic chr5:170822077(+) A-I      intronic chr5:170825523(+) A-I      intronic chr5:170836967(+) A-I      intronic chr5:170825588(+) A-I      intronic chr5:170836394(+) A-I      intronic chr5:170822036(+) A-I      intronic chr5:170828494(+) A-I      intronic chr5:170832011(+) A-I      intronic chr5:170824933(+) A-I      intronic chr5:170832103(+) A-I      intronic chr5:170828212(+) A-I      intronic chr5:170826383(+) A-I      intronic chr5:170825736(+) A-I      intronic chr5:170821981(+) A-I      intronic chr5:170825623(+) A-I      intronic chr5:170836400(+) A-I      intronic chr5:170826055(+) A-I      intronic chr5:170826437(+) A-I      intronic chr5:170825741(+) A-I      intronic chr5:170828602(+) A-I      intronic chr5:170825599(+) A-I      intronic chr5:170828242(+) A-I      intronic chr5:170823857(+) A-I      intronic chr5:170822514(+) A-I      intronic chr5:170821231(+) A-I      intronic chr5:170836397(+) A-I      intronic chr5:170836911(+) A-I      intronic chr5:170827613(+) A-I      intronic chr5:170826493(+) A-I      intronic chr5:170825598(+) A-I      intronic chr5:170825517(+) A-I      intronic chr5:170828566(+) A-I      intronic chr5:170828667(+) A-I      intronic chr5:170825613(+) A-I      intronic chr5:170836997(+) A-I      intronic chr5:170826117(+) A-I      intronic chr5:170828274(+) A-I      intronic chr5:170825928(+) A-I      intronic chr5:170836462(+) A-I      intronic chr5:170828211(+) A-I      intronic chr5:170825668(+) A-I      intronic chr5:170832006(+) A-I      intronic chr5:170820939(+) A-I      intronic chr5:170828570(+) A-I      intronic chr5:170822027(+) A-I      intronic chr5:170825641(+) A-I      intronic chr5:170825887(+) A-I      intronic chr5:170828251(+) A-I      intronic chr5:170821233(+) A-I      intronic chr5:170828152(+) A-I      intronic chr5:170831995(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NPM1	chr5:170836785(+) A-I intron -    15258596 chr5:170836911(+) A-I intron -    15258596 chr5:170836928(+) A-I intron -    15258596 chr5:170825641(+) A-I intron -    22327324 chr5:170836400(+) A-I intron -    22327324 chr5:170823856(+) A-I intron -    21960545 chr5:170828615(+) A-I intron -    21960545 chr5:170836335(+) A-I intron -    21960545 chr5:170817743(+) C-T intron -    22484847 chr5:170821138(+) T-C intron -    22484847 chr5:170821139(+) G-A intron -    22484847 chr5:170821359(+) A-G intron -    22484847 chr5:170821981(+) A-G intron -    22484847 chr5:170822007(+) A-G intron -    22484847 chr5:170822023(+) A-G intron -    22484847 chr5:170822024(+) A-G intron -    22484847 chr5:170822025(+) A-G intron -    22484847 chr5:170822378(+) G-A intron -    22484847 chr5:170822397(+) A-G intron -    22484847 chr5:170822443(+) A-G intron -    22484847 chr5:170822484(+) A-G intron -    22484847 chr5:170822487(+) A-G intron -    22484847 chr5:170822489(+) A-G intron -    22484847 chr5:170822514(+) A-G intron -    22484847 chr5:170823856(+) A-G intron -    22484847 chr5:170823857(+) A-G intron -    22484847 chr5:170823950(+) T-C intron -    22484847 chr5:170824806(+) C-T intron -    22484847 chr5:170824823(+) G-T intron -    22484847 chr5:170824892(+) T-G intron -    22484847 chr5:170824933(+) A-G intron -    22484847 chr5:170824947(+) C-A intron -    22484847 chr5:170824948(+) A-C intron -    22484847 chr5:170825504(+) T-G intron -    22484847 chr5:170825517(+) A-G intron -    22484847 chr5:170825538(+) A-G intron -    22484847 chr5:170825588(+) A-G intron -    22484847 chr5:170825628(+) A-G intron -    22484847 chr5:170825641(+) A-G intron -    22484847 chr5:170825654(+) A-G intron -    22484847 chr5:170825917(+) A-G intron -    22484847 chr5:170825994(+) A-G intron -    22484847 chr5:170826020(+) A-G intron -    22484847 chr5:170826021(+) A-G intron -    22484847 chr5:170826058(+) A-G intron -    22484847 chr5:170826383(+) A-G intron -    22484847 chr5:170826509(+) A-G intron -    22484847 chr5:170827504(+) G-A intron -    22484847 chr5:170828147(+) A-G intron -    22484847 chr5:170828152(+) A-G intron -    22484847 chr5:170828206(+) A-G intron -    22484847 chr5:170828219(+) A-G intron -    22484847 chr5:170828242(+) A-G intron -    22484847 chr5:170828255(+) A-G intron -    22484847 chr5:170828472(+) A-G intron -    22484847 chr5:170828566(+) A-G intron -    22484847 chr5:170828567(+) A-G intron -    22484847 chr5:170828570(+) A-G intron -    22484847 chr5:170828602(+) A-G intron -    22484847 chr5:170828615(+) A-G intron -    22484847 chr5:170828630(+) T-C intron -    22484847 chr5:170828667(+) A-G intron -    22484847 chr5:170831995(+) A-G intron -    22484847 chr5:170832059(+) A-G intron -    22484847 chr5:170836335(+) A-G intron -    22484847 chr5:170836396(+) A-G intron -    22484847 chr5:170836397(+) A-G intron -    22484847 chr5:170836398(+) A-G intron -    22484847 chr5:170836400(+) A-G intron -    22484847 chr5:170836450(+) A-G intron -    22484847 chr5:170836462(+) A-G intron -    22484847 chr5:170836898(+) A-G intron -    22484847 chr5:170836902(+) A-G intron -    22484847 chr5:170836911(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NPM1	chr5:170814968-170814969(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814974-170814975(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170814998-170814999(+) m6A 5'UTR//CDS//exon       27773535//22575960 chr5:170817061-170817062(+) m6A CDS//exon//intron       27773535//22575960 chr5:170817142-170817143(+) m6A exon//intron       27773535 chr5:170817155-170817156(+) m6A exon//intron       27773535 chr5:170818270-170818271(+) m6A exon//intron       - chr5:170818348-170818349(+) Y 5'UTR//CDS//exon       26075521 chr5:170818789-170818790(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819762-170819763(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170819877-170819878(+) m6A exon//intron       24981863//27773535//22575960 chr5:170819928-170819929(+) m6A CDS//exon       24981863//27773535//22575960 chr5:170827812-170827813(+) m6A exon//intron       24981863//27773535//22575960 chr5:170827897-170827898(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170827904-170827905(+) m6A CDS//exon//intron       24981863//27773535//27371828//22575960 chr5:170832307-170832308(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832325-170832326(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832335-170832336(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832344-170832345(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832355-170832356(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832372-170832373(+) m6A CDS//exon       24981863//27773535//27371828//22575960 chr5:170832430-170832431(+) m6A exon//intron       24981863//27773535//22575960 chr5:170832473-170832474(+) m6A exon//intron       24981863//27773535 chr5:170832696-170832697(+) m6A exon//intron       24981863 chr5:170832733-170832734(+) m6A exon//intron       24981863 chr5:170833409-170833410(+) m6A 3'UTR//intron       24981863 chr5:170833468-170833469(+) m6A 3'UTR//intron       24981863 chr5:170833506-170833507(+) m6A 3'UTR//intron       27773535 chr5:170833574-170833575(+) m6A 3'UTR//intron       27773535 chr5:170833626-170833627(+) m6A 3'UTR//intron       27773535 chr5:170837582-170837583(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837665-170837666(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837754-170837755(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837802-170837803(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837824-170837825(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837843-170837844(+) m6A 3'UTR//exon       24981863//27773535 chr5:170837867-170837868(+) m6A 3'UTR//exon       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NPM1	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hiv1-miR-TAR-3p	l-685,458       5479543 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-3p
Interactor2: NPM1

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//IP//Northern blot//RT-PCR//Western blot
Support Database	VmiReg

References:

PMID	23938024	Target region	3'UTR
Source	VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Bioinformatic predictions and reporter gene activity assays identified regulatory elements complementary and responsive to miR-TAR-5p and miR-TAR-3p in the 3' untranslated region (UTR) of several candidate genes involved in apoptosis and cell survival. These include Caspase 8, Aiolos, Ikaros and Nucleophosmin (NPM)/B23.