Basic Information:

  VIRBase ID:  

VHID00701405

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9950

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-3p:  MIMAT0006017          CASP8:  NR_111983     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-3p	CASP8
miRBase Accession/Entrez ID	MIMAT0006017	841
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALPS2B//CAP4//Casp-8//FLICE//MACH//MCH5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CASP8	chr2:202109994(+) A-I      intronic chr2:202145859(+) A-I      intronic chr2:202145822(+) A-I      intronic chr2:202143477(+) A-I      intronic chr2:202143464(+) A-I      intronic chr2:202143452(+) A-I      intronic chr2:202117989(+) A-I      intronic chr2:202119886(+) A-I      intronic chr2:202117988(+) A-I      intronic chr2:202117986(+) A-I      intronic chr2:202117974(+) A-I      intronic chr2:202117973(+) A-I      intronic chr2:202112574(+) A-I      intronic chr2:202119887(+) A-I      intronic chr2:202120021(+) A-I      intronic chr2:202117932(+) A-I      intronic chr2:202120022(+) A-I      intronic chr2:202112777(+) A-I      intronic chr2:202114403(+) A-I      intronic chr2:202120023(+) A-I      intronic chr2:202120036(+) A-I      intronic chr2:202110057(+) A-I      intronic chr2:202129434(+) A-I      intronic chr2:202133774(+) A-I      intronic chr2:202142448(+) A-I      intronic chr2:202142449(+) A-I      intronic chr2:202145861(+) A-I      intronic chr2:202110238(+) A-I      intronic chr2:202112641(+) A-I      intronic chr2:202143498(+) A-I      intronic chr2:202110647(+) A-I      intronic chr2:202111670(+) A-I      intronic chr2:202112282(+) A-I      intronic chr2:202152042(+) A-I      3'UTR chr2:202152054(+) A-I      3'UTR chr2:202152055(+) A-I      3'UTR chr2:202152076(+) A-I      3'UTR chr2:202152101(+) A-I      3'UTR chr2:202145860(+) A-I      intronic chr2:202119965(+) A-I      intronic chr2:202119981(+) A-I      intronic chr2:202120564(+) A-I      intronic chr2:202120604(+) A-I      intronic chr2:202120617(+) A-I      intronic chr2:202120618(+) A-I      intronic chr2:202120715(+) A-I      intronic chr2:202120716(+) A-I      intronic chr2:202120755(+) A-I      intronic chr2:202121622(+) A-I      intronic chr2:202121721(+) A-I      intronic chr2:202133218(+) A-I      intronic chr2:202133219(+) A-I      intronic chr2:202117138(+) A-I      intronic chr2:202101538(+) A-I      intronic chr2:202110038(+) A-I      intronic chr2:202110153(+) A-I      intronic chr2:202110757(+) A-I      intronic chr2:202111742(+) A-I      intronic chr2:202111758(+) A-I      intronic chr2:202112301(+) A-I      intronic chr2:202112302(+) A-I      intronic chr2:202113714(+) A-I      intronic chr2:202113715(+) A-I      intronic chr2:202114184(+) A-I      intronic chr2:202114389(+) A-I      intronic chr2:202116113(+) A-I      intronic chr2:202116150(+) A-I      intronic chr2:202117777(+) A-I      intronic chr2:202117808(+) A-I      intronic chr2:202117959(+) A-I      intronic chr2:202118544(+) A-I      intronic chr2:202118649(+) A-I      intronic chr2:202119938(+) A-I      intronic chr2:202151982(+) A-I      3'UTR chr2:202151992(+) A-I      3'UTR chr2:202152006(+) A-I      3'UTR chr2:202152103(+) A-I      3'UTR chr2:202152030(+) A-I      3'UTR chr2:202152090(+) A-I      3'UTR chr2:202151549(+) A-I      3'UTR chr2:202152109(+) A-I      3'UTR chr2:202111665(+) A-I      intronic chr2:202129978(+) A-I      intronic chr2:202133090(+) A-I      intronic chr2:202114176(+) A-I      intronic chr2:202145803(+) A-I      intronic chr2:202111762(+) A-I      intronic chr2:202116505(+) A-I      intronic chr2:202124119(+) A-I      intronic chr2:202145890(+) A-I      intronic chr2:202111646(+) A-I      intronic chr2:202110063(+) A-I      intronic chr2:202117825(+) A-I      intronic chr2:202145916(+) A-I      intronic chr2:202142445(+) A-I      intronic chr2:202143339(+) A-I      intronic chr2:202129979(+) A-I      intronic chr2:202117980(+) A-I      intronic chr2:202124167(+) A-I      intronic chr2:202144585(+) A-I      intronic chr2:202129991(+) A-I      intronic chr2:202121998(+) A-I      intronic chr2:202111832(+) A-I      intronic chr2:202152000(+) A-I      3'UTR chr2:202152091(+) A-I      3'UTR chr2:202152001(+) A-I      3'UTR chr2:202151604(+) A-I      3'UTR chr2:202151478(+) A-I      3'UTR chr2:202151998(+) A-I      3'UTR chr2:202151456(+) A-I      3'UTR chr2:202152106(+) A-I      3'UTR chr2:202152017(+) A-I      3'UTR chr2:202152046(+) A-I      3'UTR chr2:202142607(+) A-I      3'UTR chr2:202152078(+) A-I      3'UTR chr2:202152023(+) A-I      3'UTR chr2:202152047(+) A-I      3'UTR chr2:202151365(+) A-I      3'UTR chr2:202151438(+) A-I      3'UTR chr2:202142553(+) A-I      3'UTR chr2:202151389(+) A-I      3'UTR chr2:202151362(+) A-I      3'UTR chr2:202152105(+) A-I      3'UTR chr2:202143279(+) A-I      intronic chr2:202111664(+) A-I      intronic chr2:202113679(+) A-I      intronic chr2:202114368(+) A-I      intronic chr2:202130908(+) A-I      intronic chr2:202111858(+) A-I      intronic chr2:202132749(+) A-I      intronic chr2:202130019(+) A-I      intronic chr2:202114430(+) A-I      intronic chr2:202118590(+) A-I      intronic chr2:202143435(+) A-I      intronic chr2:202111771(+) A-I      intronic chr2:202112755(+) A-I      intronic chr2:202130842(+) A-I      intronic chr2:202111857(+) A-I      intronic chr2:202118589(+) A-I      intronic chr2:202130000(+) A-I      intronic chr2:202110064(+) A-I      intronic chr2:202117731(+) A-I      intronic chr2:202145957(+) A-I      intronic chr2:202129952(+) A-I      intronic chr2:202132724(+) A-I      intronic chr2:202110130(+) A-I      intronic chr2:202145972(+) A-I      intronic chr2:202112771(+) A-I      intronic chr2:202122146(+) A-I      intronic chr2:202111765(+) A-I      intronic chr2:202110225(+) A-I      intronic chr2:202142523(+) A-I      NonSyn:Lys->Glu

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CASP8	chr2:202151362(+) A-I exon 3'UTR    15342557   //21960545   //22327324 chr2:202152062(+) A-I exon 3'UTR    15342557 chr2:202152078(+) A-I exon 3'UTR    15342557 chr2:202152091(+) A-I exon 3'UTR    15342557 chr2:202152106(+) A-I exon 3'UTR    15342557 chr2:202152108(+) A-I exon 3'UTR    15342557 chr2:202151362(+) A-G intron -    21725310   //22484847 chr2:202152106(+) A-G intron -    21725310 chr2:202110081(+) A-G intron -    22484847 chr2:202110144(+) A-G intron -    22484847 chr2:202110161(+) A-G intron -    22484847 chr2:202112507(+) A-G intron -    22484847 chr2:202114423(+) A-G intron -    22484847 chr2:202117023(+) A-G intron -    22484847 chr2:202117731(+) A-G intron -    22484847 chr2:202117811(+) A-G intron -    22484847 chr2:202117825(+) A-G intron -    22484847 chr2:202117946(+) A-G intron -    22484847 chr2:202117947(+) A-G intron -    22484847 chr2:202117980(+) A-G intron -    22484847 chr2:202124119(+) A-G intron -    22484847 chr2:202124167(+) A-G intron -    22484847 chr2:202130908(+) A-G intron -    22484847 chr2:202132698(+) A-G intron -    22484847 chr2:202143279(+) A-G intron -    22484847 chr2:202143336(+) C-T intron -    22484847 chr2:202143339(+) A-G intron -    22484847 chr2:202145916(+) A-G intron -    22484847 chr2:202151998(+) A-G intron -    22484847 chr2:202152047(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CASP8	chr2:202098274-202098275(+) m1A 5'UTR//exon       26863196 chr2:202105115-202105116(+) m6A exon//intron       24981863 chr2:202105138-202105139(+) m6A exon//intron       24981863//22608085 chr2:202105151-202105152(+) m6A exon//intron       24981863//22608085 chr2:202105252-202105253(+) m6A exon//intron       24981863//27773535//22608085 chr2:202105267-202105268(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105308-202105309(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105340-202105341(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105348-202105349(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105367-202105368(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105374-202105375(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105380-202105381(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105392-202105393(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105401-202105402(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105406-202105407(+) m6A exon//intron       24209618//24981863//27773535//22608085 chr2:202105444-202105445(+) m6A exon//intron       24981863//27773535//22608085 chr2:202105472-202105473(+) m6A exon//intron       24981863//27773535//22608085 chr2:202105508-202105509(+) m6A exon//intron       24981863//27773535 chr2:202105531-202105532(+) m6A exon//intron       24981863//27773535 chr2:202105575-202105576(+) m6A exon//intron       24981863//27773535 chr2:202105631-202105632(+) m6A exon//intron       24981863//27773535 chr2:202105646-202105647(+) m6A exon//intron       24981863//27773535 chr2:202105727-202105728(+) m6A exon//intron       24981863//27773535 chr2:202105876-202105877(+) m6A exon//intron       24981863//27773535//22608085 chr2:202105922-202105923(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106014-202106015(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106060-202106061(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106070-202106071(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106094-202106095(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106123-202106124(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106140-202106141(+) m6A exon//intron       24981863//27773535//22608085 chr2:202106158-202106159(+) m6A exon//intron       24981863//22608085 chr2:202106194-202106195(+) m6A exon//intron       24981863//22608085 chr2:202106241-202106242(+) m6A exon//intron       24981863//22608085 chr2:202106375-202106376(+) m6A exon//intron       24981863 chr2:202106455-202106456(+) m6A exon//intron       24981863//27773535 chr2:202106461-202106462(+) m6A exon//intron       24981863//27773535 chr2:202106479-202106480(+) m6A exon//intron       24981863//27773535 chr2:202106517-202106518(+) m6A exon//intron       24981863//27773535 chr2:202106739-202106740(+) m6A exon//intron       24981863 chr2:202106754-202106755(+) m6A exon//intron       24981863 chr2:202122836-202122837(+) m6A 5'UTR//intron       24981863 chr2:202123000-202123001(+) m6A CDS//intron       24981863 chr2:202123066-202123067(+) m6A CDS//exon//intron       24981863 chr2:202123074-202123075(+) m6A CDS//exon//intron       24981863 chr2:202131213-202131214(+) m6A CDS//exon//intron       24209618//24981863//22608085 chr2:202131244-202131245(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22608085 chr2:202131252-202131253(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22608085 chr2:202131291-202131292(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//22608085 chr2:202131316-202131317(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//22608085 chr2:202131349-202131350(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//26404942//22608085 chr2:202131421-202131422(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//26404942//22608085 chr2:202131447-202131448(+) m6A 3'UTR//CDS//exon//intron       24284625//24981863//22608085 chr2:202131475-202131476(+) m6A 3'UTR//CDS//exon//intron       24284625//22608085 chr2:202131482-202131483(+) m6A 3'UTR//CDS//exon//intron       24284625//22608085 chr2:202141581-202141582(+) m6A CDS//exon//intron       24209618 chr2:202141647-202141648(+) m6A CDS//exon//intron       24209618 chr2:202141664-202141665(+) m6A 3'UTR//CDS//exon//intron       24209618 chr2:202141675-202141676(+) m6A 3'UTR//CDS//exon//intron       24209618 chr2:202141701-202141702(+) m6A exon//intron       24209618 chr2:202141763-202141764(+) m6A exon//intron       24209618 chr2:202149643-202149644(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149658-202149659(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149691-202149692(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149719-202149720(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149788-202149789(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149852-202149853(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr2:202149976-202149977(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202149990-202149991(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr2:202151216-202151217(+) m6A CDS//exon       22608085 chr2:202151249-202151250(+) m6A CDS//exon       - chr2:202151259-202151260(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CASP8	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hiv1-miR-TAR-3p	l-685,458       5479543 Pha-665752       10461815

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-3p
Interactor2: CASP8

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//IP//Northern blot//RT-PCR//Western blot
Prediction-Evidence	cRep//miRanda//PITA//RNAHybrid
Support Database	RepTar//VmiReg

References:

PMID	23938024	Target region	3'UTR
Source	RepTar//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Bioinformatic predictions and reporter gene activity assays identified regulatory elements complementary and responsive to miR-TAR-5p and miR-TAR-3p in the 3' untranslated region (UTR) of several candidate genes involved in apoptosis and cell survival. These include Caspase 8, Aiolos, Ikaros and Nucleophosmin (NPM)/B23.