Basic Information:

  VIRBase ID:  

VHID00699535

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-5p:  MIMAT0006016          DERL1:  NM_001363963     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-5p	DERL1
miRBase Accession/Entrez ID	MIMAT0006016	79139
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DER-1//DER1//derlin-1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DERL1	chr8:124045920(-) A-I      intronic chr8:124045821(-) A-I      intronic chr8:124045754(-) A-I      intronic chr8:124045161(-) A-I      intronic chr8:124045835(-) A-I      intronic chr8:124045900(-) A-I      intronic chr8:124045376(-) A-I      intronic chr8:124045265(-) A-I      intronic chr8:124045240(-) A-I      intronic chr8:124045209(-) A-I      intronic chr8:124045767(-) A-I      intronic chr8:124045378(-) A-I      intronic chr8:124044467(-) A-I      intronic chr8:124044472(-) A-I      intronic chr8:124045871(-) A-I      intronic chr8:124045976(-) A-I      intronic chr8:124045164(-) A-I      intronic chr8:124043702(-) A-I      intronic chr8:124045223(-) A-I      intronic chr8:124045182(-) A-I      intronic chr8:124044542(-) A-I      intronic chr8:124042217(-) A-I      intronic chr8:124044477(-) A-I      intronic chr8:124045983(-) A-I      intronic chr8:124044554(-) A-I      intronic chr8:124044550(-) A-I      intronic chr8:124044607(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DERL1	chr8:124043702(-) A-G intron -    22484847 chr8:124044550(-) A-G intron -    22484847 chr8:124045164(-) A-G intron -    22484847 chr8:124045240(-) A-G intron -    22484847 chr8:124045265(-) A-G intron -    22484847 chr8:124045378(-) A-G intron -    22484847 chr8:124045739(-) A-G intron -    22484847 chr8:124045767(-) A-G intron -    22484847 chr8:124045861(-) A-G intron -    22484847 chr8:124045871(-) A-G intron -    22484847 chr8:124045921(-) A-G intron -    22484847 chr8:124045976(-) A-G intron -    22484847 chr8:124045983(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DERL1	chr8:124027128-124027129(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027150-124027151(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027330-124027331(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027345-124027346(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr8:124027448-124027449(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr8:124027475-124027476(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085 chr8:124027558-124027559(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085 chr8:124027594-124027595(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:124027693-124027694(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:124027725-124027726(-) m6A CDS//exon       24284625//24209618//27773535//27371828//22608085 chr8:124054345-124054346(-) m6A CDS       27773536 chr8:124054354-124054355(-) m6A CDS       27773536 chr8:124054453-124054454(-) m6A 5'UTR       24981863//27371828//27773536 chr8:124054589-124054590(-) m6A 5'UTR       25456834//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DERL1	Chromatin HeLa-S3 cells|K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-5p
Interactor2: DERL1

Evidence Support:

Prediction-Evidence	miRanda//PITA
Support Database	VmiReg