Basic Information:

  VIRBase ID:  

VHID00698734

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9374

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-5p:  MIMAT0006016          PIAS4:  NM_015897     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-5p	PIAS4
miRBase Accession/Entrez ID	MIMAT0006016	51588
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PIAS-gamma//Piasg//PIASY//ZMIZ6

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIAS4	chr19:4026810(+) A-I      intronic chr19:4026774(+) A-I      intronic chr19:4026750(+) A-I      intronic chr19:4026704(+) A-I      intronic chr19:4026341(+) A-I      intronic chr19:4026320(+) A-I      intronic chr19:4026270(+) A-I      intronic chr19:4026235(+) A-I      intronic chr19:4023438(+) A-I      intronic chr19:4023085(+) A-I      intronic chr19:4023300(+) A-I      intronic chr19:4023072(+) A-I      intronic chr19:4023049(+) A-I      intronic chr19:4022915(+) A-I      intronic chr19:4022914(+) A-I      intronic chr19:4021330(+) A-I      intronic chr19:4023262(+) A-I      intronic chr19:4023205(+) A-I      intronic chr19:4023203(+) A-I      intronic chr19:4017755(+) A-I      intronic chr19:4022458(+) A-I      intronic chr19:4024943(+) A-I      intronic chr19:4025957(+) A-I      intronic chr19:4023022(+) A-I      intronic chr19:4025843(+) A-I      intronic chr19:4029759(+) A-I      intronic chr19:4026404(+) A-I      intronic chr19:4027188(+) A-I      intronic chr19:4029782(+) A-I      intronic chr19:4021347(+) A-I      intronic chr19:4025951(+) A-I      intronic chr19:4027061(+) A-I      intronic chr19:4026017(+) A-I      intronic chr19:4026224(+) A-I      intronic chr19:4023291(+) A-I      intronic chr19:4026231(+) A-I      intronic chr19:4029907(+) A-I      intronic chr19:4021380(+) A-I      intronic chr19:4027186(+) A-I      intronic chr19:4022764(+) A-I      intronic chr19:4027254(+) A-I      intronic chr19:4029925(+) A-I      intronic chr19:4026814(+) A-I      intronic chr19:4022955(+) A-I      intronic chr19:4025921(+) A-I      intronic chr19:4029996(+) A-I      intronic chr19:4025810(+) A-I      intronic chr19:4024864(+) A-I      intronic chr19:4023367(+) A-I      intronic chr19:4027233(+) A-I      intronic chr19:4027248(+) A-I      intronic chr19:4029771(+) A-I      intronic chr19:4024963(+) A-I      intronic chr19:4027166(+) A-I      intronic chr19:4025888(+) A-I      intronic chr19:4025920(+) A-I      intronic chr19:4026707(+) A-I      intronic chr19:4022901(+) A-I      intronic chr19:4021251(+) A-I      intronic chr19:4021250(+) A-I      intronic chr19:4029921(+) A-I      intronic chr19:4022983(+) A-I      intronic chr19:4023009(+) A-I      intronic chr19:4029692(+) A-I      intronic chr19:4030605(+) A-I      intronic chr19:4023410(+) A-I      intronic chr19:4026925(+) A-I      intronic chr19:4023364(+) A-I      intronic chr19:4025894(+) A-I      intronic chr19:4017991(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIAS4	chr19:4012991-4012992(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:4013061-4013062(+) Am CDS//exon       - chr19:4013082-4013083(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:4013101-4013102(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:4013137-4013138(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:4013187-4013188(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:4013246-4013247(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:4013268-4013269(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr19:4018708-4018709(+) m6A exon//intron       - chr19:4024042-4024043(+) m6A CDS//exon//intron       - chr19:4024091-4024092(+) m6A CDS//exon//intron       - chr19:4024111-4024112(+) m6A CDS//exon//intron       - chr19:4028146-4028147(+) m6A CDS//exon       - chr19:4028521-4028522(+) m6A CDS//exon       24284625 chr19:4028542-4028543(+) m6A CDS//exon       24284625 chr19:4028835-4028836(+) m6A CDS       24284625//24981863 chr19:4033456-4033457(+) m6A CDS       24284625 chr19:4037739-4037740(+) m6A CDS       24284625//24209618//25456834 chr19:4037751-4037752(+) m6A CDS       24284625//24209618//25456834 chr19:4038029-4038030(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr19:4038096-4038097(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr19:4038109-4038110(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr19:4038119-4038120(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr19:4038191-4038192(+) m6A 3'UTR       24981863 chr19:4038556-4038557(+) m6A 3'UTR       24284625//24209618 chr19:4038575-4038576(+) m6A 3'UTR       24284625//24209618 chr19:4038685-4038686(+) m6A 3'UTR       24284625//24209618 chr19:4039062-4039063(+) m6A 3'UTR       24284625 chr19:4039166-4039167(+) m6A 3'UTR       24284625 chr19:4039171-4039172(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PIAS4	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-5p
Interactor2: PIAS4

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Western blot
Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	21133815	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	293T cells	Interactor2 expression	None
Description	Microarray analysis of RNA isolated from TAR transfected cells using an Affymetrix human focus array identified 18 human genes that were downregulated and 14 genes that were upregulated. Further validation of four of these genes showed possible links to apoptosis and cell survival including ERCC1 (excision repair cross complementing-group 1), PIASg (protein inhibitor of acti-vated STATg), GIT2 (GPCR interacting protein) and IER3 (intermediate early response 3).