Basic Information:

  VIRBase ID:  

VHID00697900

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9949

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-TAR-5p:  MIMAT0006016          IKZF1:  NM_001291844     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-TAR-5p	IKZF1
miRBase Accession/Entrez ID	MIMAT0006016	10320
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CVID13//Hs.54452//IK1//IKAROS//LyF-1//LYF1//PPP1R92//PRO0758//ZNFN1A1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	IKZF1	chr7:50353888(+) A-I      intronic chr7:50365256(+) A-I      intronic chr7:50365275(+) A-I      intronic chr7:50426803(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IKZF1	chr7:50467699-50467700(+) m6A CDS//exon//intron       - chr7:50467864-50467865(+) m6A CDS//exon       27371828 chr7:50467879-50467880(+) m6A CDS//exon       27371828 chr7:50467951-50467952(+) m6A CDS//exon       27371828 chr7:50467960-50467961(+) m6A CDS//exon       27371828 chr7:50468095-50468096(+) m6A CDS//exon       25456834//27371828 chr7:50468159-50468160(+) m6A CDS//exon       25456834 chr7:50468266-50468267(+) m6A CDS//exon       25456834 chr7:50468349-50468350(+) m6A 3'UTR       24209618//25456834//24981863//27371828 chr7:50468379-50468380(+) m6A 3'UTR       24209618//25456834//24981863//27371828 chr7:50468412-50468413(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468417-50468418(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468422-50468423(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468427-50468428(+) m6A 3'UTR       24209618//25456834//24981863 chr7:50468550-50468551(+) m6A 3'UTR       - chr7:50468578-50468579(+) m6A 3'UTR       - chr7:50468666-50468667(+) m6A 3'UTR       - chr7:50470000-50470001(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IKZF1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-TAR-5p
Interactor2: IKZF1

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//IP//Northern blot//RT-PCR//Western blot
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VmiReg

References:

PMID	23938024	Target region	3'UTR
Source	RepTar//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Bioinformatic predictions and reporter gene activity assays identified regulatory elements complementary and responsive to miR-TAR-5p and miR-TAR-3p in the 3' untranslated region (UTR) of several candidate genes involved in apoptosis and cell survival. These include Caspase 8, Aiolos, Ikaros and Nucleophosmin (NPM)/B23.