Basic Information:

  VIRBase ID:  

VHID00691891

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-H1:  MIMAT0004480          AATF:  NM_012138     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-H1	AATF
miRBase Accession/Entrez ID	MIMAT0004480	26574
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BFR2//CHE-1//CHE1//DED

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AATF	chr17:35381205(+) A-I      intronic chr17:35353498(+) A-I      intronic chr17:35381243(+) A-I      intronic chr17:35353653(+) A-I      intronic chr17:35313180(+) A-I      intronic chr17:35315689(+) A-I      intronic chr17:35353648(+) A-I      intronic chr17:35353643(+) A-I      intronic chr17:35317574(+) A-I      intronic chr17:35381262(+) A-I      intronic chr17:35381244(+) A-I      intronic chr17:35381258(+) A-I      intronic chr17:35381202(+) A-I      intronic chr17:35353469(+) A-I      intronic chr17:35353678(+) A-I      intronic chr17:35365964(+) A-I      intronic chr17:35387482(+) A-I      intronic chr17:35353476(+) A-I      intronic chr17:35328772(+) A-I      intronic chr17:35328778(+) A-I      intronic chr17:35328784(+) A-I      intronic chr17:35328786(+) A-I      intronic chr17:35328801(+) A-I      intronic chr17:35353481(+) A-I      intronic chr17:35381211(+) A-I      intronic chr17:35381237(+) A-I      intronic chr17:35381242(+) A-I      intronic chr17:35353672(+) A-I      intronic chr17:35320266(+) A-I      intronic chr17:35317393(+) A-I      intronic chr17:35317514(+) A-I      intronic chr17:35317394(+) A-I      intronic chr17:35316542(+) A-I      intronic chr17:35316545(+) A-I      intronic chr17:35311417(+) A-I      intronic chr17:35311423(+) A-I      intronic chr17:35311467(+) A-I      intronic chr17:35311602(+) A-I      intronic chr17:35313163(+) A-I      intronic chr17:35316560(+) A-I      intronic chr17:35316568(+) A-I      intronic chr17:35316589(+) A-I      intronic chr17:35313199(+) A-I      intronic chr17:35313249(+) A-I      intronic chr17:35313260(+) A-I      intronic chr17:35316433(+) A-I      intronic chr17:35411086(+) A-I      intronic chr17:35363323(+) A-I      intronic chr17:35364506(+) A-I      intronic chr17:35386877(+) A-I      intronic chr17:35363319(+) A-I      intronic chr17:35361605(+) A-I      intronic chr17:35361487(+) A-I      intronic chr17:35360923(+) A-I      intronic chr17:35360866(+) A-I      intronic chr17:35360865(+) A-I      intronic chr17:35360859(+) A-I      intronic chr17:35316189(+) A-I      intronic chr17:35316190(+) A-I      intronic chr17:35316249(+) A-I      intronic chr17:35316431(+) A-I      intronic chr17:35339814(+) A-I      intronic chr17:35361473(+) A-I      intronic chr17:35342052(+) A-I      intronic chr17:35342061(+) A-I      intronic chr17:35405700(+) A-I      intronic chr17:35405725(+) A-I      intronic chr17:35405733(+) A-I      intronic chr17:35405769(+) A-I      intronic chr17:35405786(+) A-I      intronic chr17:35405808(+) A-I      intronic chr17:35406645(+) A-I      intronic chr17:35406651(+) A-I      intronic chr17:35406676(+) A-I      intronic chr17:35406847(+) A-I      intronic chr17:35406848(+) A-I      intronic chr17:35342064(+) A-I      intronic chr17:35342175(+) A-I      intronic chr17:35344318(+) A-I      intronic chr17:35353587(+) A-I      intronic chr17:35353591(+) A-I      intronic chr17:35411072(+) A-I      intronic chr17:35353623(+) A-I      intronic chr17:35353685(+) A-I      intronic chr17:35353703(+) A-I      intronic chr17:35320304(+) A-I      intronic chr17:35358384(+) A-I      intronic chr17:35358427(+) A-I      intronic chr17:35360801(+) A-I      intronic chr17:35316354(+) A-I      intronic chr17:35316325(+) A-I      intronic chr17:35316319(+) A-I      intronic chr17:35316299(+) A-I      intronic chr17:35316296(+) A-I      intronic chr17:35316295(+) A-I      intronic chr17:35316264(+) A-I      intronic chr17:35313852(+) A-I      intronic chr17:35313853(+) A-I      intronic chr17:35313963(+) A-I      intronic chr17:35313979(+) A-I      intronic chr17:35313980(+) A-I      intronic chr17:35314019(+) A-I      intronic chr17:35314021(+) A-I      intronic chr17:35314062(+) A-I      intronic chr17:35314148(+) A-I      intronic chr17:35315647(+) A-I      intronic chr17:35386658(+) A-I      intronic chr17:35392900(+) A-I      intronic chr17:35386459(+) A-I      intronic chr17:35386004(+) A-I      intronic chr17:35386003(+) A-I      intronic chr17:35315676(+) A-I      intronic chr17:35315687(+) A-I      intronic chr17:35385923(+) A-I      intronic chr17:35385922(+) A-I      intronic chr17:35385873(+) A-I      intronic chr17:35379000(+) A-I      intronic chr17:35369588(+) A-I      intronic chr17:35369492(+) A-I      intronic chr17:35369415(+) A-I      intronic chr17:35369374(+) A-I      intronic chr17:35367642(+) A-I      intronic chr17:35367499(+) A-I      intronic chr17:35366570(+) A-I      intronic chr17:35366567(+) A-I      intronic chr17:35366017(+) A-I      intronic chr17:35365992(+) A-I      intronic chr17:35365981(+) A-I      intronic chr17:35365943(+) A-I      intronic chr17:35365938(+) A-I      intronic chr17:35364612(+) A-I      intronic chr17:35392910(+) A-I      intronic chr17:35392899(+) A-I      intronic chr17:35392645(+) A-I      intronic chr17:35392406(+) A-I      intronic chr17:35392301(+) A-I      intronic chr17:35392256(+) A-I      intronic chr17:35392211(+) A-I      intronic chr17:35387460(+) A-I      intronic chr17:35387447(+) A-I      intronic chr17:35387446(+) A-I      intronic chr17:35387436(+) A-I      intronic chr17:35387408(+) A-I      intronic chr17:35387008(+) A-I      intronic chr17:35387002(+) A-I      intronic chr17:35386890(+) A-I      intronic chr17:35386889(+) A-I      intronic chr17:35320308(+) A-I      intronic chr17:35320325(+) A-I      intronic chr17:35320371(+) A-I      intronic chr17:35321205(+) A-I      intronic chr17:35321700(+) A-I      intronic chr17:35323690(+) A-I      intronic chr17:35325653(+) A-I      intronic chr17:35331274(+) A-I      intronic chr17:35316510(+) A-I      intronic chr17:35316655(+) A-I      intronic chr17:35316607(+) A-I      intronic chr17:35316596(+) A-I      intronic chr17:35316590(+) A-I      intronic chr17:35331250(+) A-I      intronic chr17:35358606(+) A-I      intronic chr17:35386564(+) A-I      intronic chr17:35385936(+) A-I      intronic chr17:35369474(+) A-I      intronic chr17:35393012(+) A-I      intronic chr17:35361509(+) A-I      intronic chr17:35321687(+) A-I      intronic chr17:35353475(+) A-I      intronic chr17:35311620(+) A-I      intronic chr17:35361225(+) A-I      intronic chr17:35311511(+) A-I      intronic chr17:35315727(+) A-I      intronic chr17:35314086(+) A-I      intronic chr17:35316355(+) A-I      intronic chr17:35353016(+) A-I      intronic chr17:35352996(+) A-I      intronic chr17:35366449(+) A-I      intronic chr17:35317516(+) A-I      intronic chr17:35405897(+) A-I      intronic chr17:35361028(+) A-I      intronic chr17:35364725(+) A-I      intronic chr17:35382105(+) A-I      intronic chr17:35331289(+) A-I      intronic chr17:35314209(+) A-I      intronic chr17:35324113(+) A-I      intronic chr17:35369620(+) A-I      intronic chr17:35368595(+) A-I      intronic chr17:35311617(+) A-I      intronic chr17:35316326(+) A-I      intronic chr17:35317497(+) A-I      intronic chr17:35385962(+) A-I      intronic chr17:35316255(+) A-I      intronic chr17:35316390(+) A-I      intronic chr17:35313086(+) A-I      intronic chr17:35392620(+) A-I      intronic chr17:35320298(+) A-I      intronic chr17:35315563(+) A-I      intronic chr17:35315726(+) A-I      intronic chr17:35321267(+) A-I      intronic chr17:35311447(+) A-I      intronic chr17:35386641(+) A-I      intronic chr17:35313879(+) A-I      intronic chr17:35368455(+) A-I      intronic chr17:35361310(+) A-I      intronic chr17:35405810(+) A-I      intronic chr17:35311603(+) A-I      intronic chr17:35368586(+) A-I      intronic chr17:35314022(+) A-I      intronic chr17:35392161(+) A-I      intronic chr17:35311418(+) A-I      intronic chr17:35386456(+) A-I      intronic chr17:35387442(+) A-I      intronic chr17:35315602(+) A-I      intronic chr17:35311524(+) A-I      intronic chr17:35353555(+) A-I      intronic chr17:35360878(+) A-I      intronic chr17:35365962(+) A-I      intronic chr17:35359222(+) A-I      intronic chr17:35360883(+) A-I      intronic chr17:35314146(+) A-I      intronic chr17:35369482(+) A-I      intronic chr17:35385503(+) A-I      intronic chr17:35317414(+) A-I      intronic chr17:35363399(+) A-I      intronic chr17:35361629(+) A-I      intronic chr17:35311442(+) A-I      intronic chr17:35405869(+) A-I      intronic chr17:35316622(+) A-I      intronic chr17:35364737(+) A-I      intronic chr17:35364587(+) A-I      intronic chr17:35363689(+) A-I      intronic chr17:35366862(+) A-I      intronic chr17:35321244(+) A-I      intronic chr17:35352936(+) A-I      intronic chr17:35331249(+) A-I      intronic chr17:35364510(+) A-I      intronic chr17:35314236(+) A-I      intronic chr17:35353614(+) A-I      intronic chr17:35314198(+) A-I      intronic chr17:35323682(+) A-I      intronic chr17:35363648(+) A-I      intronic chr17:35355953(+) A-I      intronic chr17:35353499(+) A-I      intronic chr17:35340830(+) A-I      intronic chr17:35321756(+) A-I      intronic chr17:35385868(+) A-I      intronic chr17:35360946(+) A-I      intronic chr17:35320256(+) A-I      intronic chr17:35317453(+) A-I      intronic chr17:35353544(+) A-I      intronic chr17:35331153(+) A-I      intronic chr17:35363327(+) A-I      intronic chr17:35315604(+) A-I      intronic chr17:35315556(+) A-I      intronic chr17:35314197(+) A-I      intronic chr17:35320202(+) A-I      intronic chr17:35364572(+) A-I      intronic chr17:35313316(+) A-I      intronic chr17:35313826(+) A-I      intronic chr17:35314226(+) A-I      intronic chr17:35315667(+) A-I      intronic chr17:35367610(+) A-I      intronic chr17:35316397(+) A-I      intronic chr17:35353668(+) A-I      intronic chr17:35316562(+) A-I      intronic chr17:35321759(+) A-I      intronic chr17:35361243(+) A-I      intronic chr17:35386963(+) A-I      intronic chr17:35325990(+) A-I      intronic chr17:35406646(+) A-I      intronic chr17:35360905(+) A-I      intronic chr17:35313894(+) A-I      intronic chr17:35315533(+) A-I      intronic chr17:35316636(+) A-I      intronic chr17:35353545(+) A-I      intronic chr17:35311656(+) A-I      intronic chr17:35339706(+) A-I      intronic chr17:35364620(+) A-I      intronic chr17:35316563(+) A-I      intronic chr17:35364507(+) A-I      intronic chr17:35317479(+) A-I      intronic chr17:35385725(+) A-I      intronic chr17:35315542(+) A-I      intronic chr17:35385453(+) A-I      intronic chr17:35392535(+) A-I      intronic chr17:35361168(+) A-I      intronic chr17:35320299(+) A-I      intronic chr17:35316424(+) A-I      intronic chr17:35345348(+) A-I      intronic chr17:35386645(+) A-I      intronic chr17:35385918(+) A-I      intronic chr17:35353682(+) A-I      intronic chr17:35317446(+) A-I      intronic chr17:35406723(+) A-I      intronic chr17:35353076(+) A-I      intronic chr17:35314156(+) A-I      intronic chr17:35369508(+) A-I      intronic chr17:35367636(+) A-I      intronic chr17:35353050(+) A-I      intronic chr17:35313977(+) A-I      intronic chr17:35314166(+) A-I      intronic chr17:35316543(+) A-I      intronic chr17:35311527(+) A-I      intronic chr17:35316250(+) A-I      intronic chr17:35314068(+) A-I      intronic chr17:35352890(+) A-I      intronic chr17:35321757(+) A-I      intronic chr17:35364777(+) A-I      intronic chr17:35358511(+) A-I      intronic chr17:35313202(+) A-I      intronic chr17:35314246(+) A-I      intronic chr17:35353119(+) A-I      intronic chr17:35386706(+) A-I      intronic chr17:35340824(+) A-I      intronic chr17:35392168(+) A-I      intronic chr17:35353613(+) A-I      intronic chr17:35360949(+) A-I      intronic chr17:35392580(+) A-I      intronic chr17:35405743(+) A-I      intronic chr17:35316695(+) A-I      intronic chr17:35313192(+) A-I      intronic chr17:35405795(+) A-I      intronic chr17:35385499(+) A-I      intronic chr17:35385907(+) A-I      intronic chr17:35313208(+) A-I      intronic chr17:35315650(+) A-I      intronic chr17:35369380(+) A-I      intronic chr17:35313717(+) A-I      intronic chr17:35316292(+) A-I      intronic chr17:35320369(+) A-I      intronic chr17:35316668(+) A-I      intronic chr17:35385863(+) A-I      intronic chr17:35316623(+) A-I      intronic chr17:35353683(+) A-I      intronic chr17:35313862(+) A-I      intronic chr17:35328737(+) A-I      intronic chr17:35360975(+) A-I      intronic chr17:35364765(+) A-I      intronic chr17:35405798(+) A-I      intronic chr17:35366560(+) A-I      intronic chr17:35313300(+) A-I      intronic chr17:35388656(+) A-I      intronic chr17:35385472(+) A-I      intronic chr17:35321213(+) A-I      intronic chr17:35386551(+) A-I      intronic chr17:35342038(+) A-I      intronic chr17:35387422(+) A-I      intronic chr17:35361042(+) A-I      intronic chr17:35364724(+) A-I      intronic chr17:35313252(+) A-I      intronic chr17:35311421(+) A-I      intronic chr17:35388577(+) A-I      intronic chr17:35361140(+) A-I      intronic chr17:35406722(+) A-I      intronic chr17:35315712(+) A-I      intronic chr17:35328828(+) A-I      intronic chr17:35329064(+) A-I      intronic chr17:35318995(+) A-I      intronic chr17:35385651(+) A-I      intronic chr17:35392929(+) A-I      intronic chr17:35385921(+) A-I      intronic chr17:35381213(+) A-I      intronic chr17:35358475(+) A-I      intronic chr17:35329077(+) A-I      intronic chr17:35311497(+) A-I      intronic chr17:35353006(+) A-I      intronic chr17:35327865(+) A-I      intronic chr17:35365954(+) A-I      intronic chr17:35353696(+) A-I      intronic chr17:35352922(+) A-I      intronic chr17:35366037(+) A-I      intronic chr17:35361040(+) A-I      intronic chr17:35328949(+) A-I      intronic chr17:35327511(+) A-I      intronic chr17:35361027(+) A-I      intronic chr17:35361192(+) A-I      intronic chr17:35388578(+) A-I      intronic chr17:35387405(+) A-I      intronic chr17:35366043(+) A-I      intronic chr17:35323665(+) A-I      intronic chr17:35328781(+) A-I      intronic chr17:35316682(+) A-I      intronic chr17:35316548(+) A-I      intronic chr17:35360940(+) A-I      intronic chr17:35361018(+) A-I      intronic chr17:35381279(+) A-I      intronic chr17:35320193(+) A-I      intronic chr17:35363340(+) A-I      intronic chr17:35368527(+) A-I      intronic chr17:35366102(+) A-I      intronic chr17:35311514(+) A-I      intronic chr17:35320368(+) A-I      intronic chr17:35313718(+) A-I      intronic chr17:35311571(+) A-I      intronic chr17:35327516(+) A-I      intronic chr17:35385713(+) A-I      intronic chr17:35313299(+) A-I      intronic chr17:35381193(+) A-I      intronic chr17:35316364(+) A-I      intronic chr17:35340813(+) A-I      intronic chr17:35327484(+) A-I      intronic chr17:35319104(+) A-I      intronic chr17:35369470(+) A-I      intronic chr17:35385828(+) A-I      intronic chr17:35367566(+) A-I      intronic chr17:35353521(+) A-I      intronic chr17:35388660(+) A-I      intronic chr17:35388661(+) A-I      intronic chr17:35365961(+) A-I      intronic chr17:35314183(+) A-I      intronic chr17:35327495(+) A-I      intronic chr17:35329074(+) A-I      intronic chr17:35388539(+) A-I      intronic chr17:35361510(+) A-I      intronic chr17:35385976(+) A-I      intronic chr17:35387470(+) A-I      intronic chr17:35311650(+) A-I      intronic chr17:35313204(+) A-I      intronic chr17:35353530(+) A-I      intronic chr17:35325974(+) A-I      intronic chr17:35361138(+) A-I      intronic chr17:35345358(+) A-I      intronic chr17:35331320(+) A-I      intronic chr17:35316524(+) A-I      intronic chr17:35388569(+) A-I      intronic chr17:35367576(+) A-I      intronic chr17:35366059(+) A-I      intronic chr17:35329173(+) A-I      intronic chr17:35385576(+) A-I      intronic chr17:35380797(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AATF	chr17:35385976(+) A-I intron -    22327324 chr17:35328828(+) A-I intron -    21960545 chr17:35328845(+) A-I intron -    21960545 chr17:35327484(+) A-G intron -    22484847 chr17:35327511(+) A-G intron -    22484847 chr17:35327516(+) A-G intron -    22484847 chr17:35328737(+) A-G intron -    22484847 chr17:35328781(+) A-G intron -    22484847 chr17:35328828(+) A-G intron -    22484847 chr17:35328949(+) A-G intron -    22484847 chr17:35329064(+) A-G intron -    22484847 chr17:35329074(+) A-G intron -    22484847 chr17:35381279(+) A-G intron -    22484847 chr17:35388569(+) A-G intron -    22484847 chr17:35388577(+) A-G intron -    22484847 chr17:35388578(+) A-G intron -    22484847 chr17:35311421(+) A-G intron -    22484847 chr17:35313826(+) A-G intron -    22484847 chr17:35352922(+) A-G intron -    22484847 chr17:35352936(+) A-G intron -    22484847 chr17:35353614(+) A-G intron -    22484847 chr17:35353682(+) A-G intron -    22484847 chr17:35361509(+) A-G intron -    22484847 chr17:35364737(+) A-G intron -    22484847 chr17:35385713(+) A-G intron -    22484847 chr17:35385962(+) A-G intron -    22484847 chr17:35385976(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AATF	chr17:35306408-35306409(+) m6A 5'UTR       24284625//24209618//25456834//24981863//22575960 chr17:35306460-35306461(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:35306471-35306472(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:35306492-35306493(+) m6A CDS       24284625//24209618//24981863//22575960 chr17:35306504-35306505(+) m6A CDS       24284625//24209618//22575960 chr17:35307595-35307596(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr17:35307618-35307619(+) m6A CDS//intron       24284625//24209618//24981863//22575960//22608085 chr17:35307624-35307625(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:35307644-35307645(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:35307672-35307673(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr17:35307686-35307687(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310234-35310235(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310282-35310283(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310337-35310338(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310446-35310447(+) m1A CDS//intron       26863196 chr17:35310464-35310465(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310488-35310489(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310506-35310507(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr17:35310565-35310566(+) Gm CDS//intron       - chr17:35310587-35310588(+) m6A CDS//intron       24209618//24981863//27773535//22575960 chr17:35311078-35311079(+) m6A CDS//intron       24209618//24981863//27773535 chr17:35311103-35311104(+) m6A CDS       24209618//24981863//27773535 chr17:35343987-35343988(+) m6A 3'UTR//CDS       27773535 chr17:35344010-35344011(+) m6A 3'UTR//CDS       27773535 chr17:35345909-35345910(+) m6A 3'UTR//CDS       24981863//26404942 chr17:35345960-35345961(+) m6A 3'UTR//CDS       24981863//26404942 chr17:35345989-35345990(+) m6A 3'UTR//CDS       24981863//26404942 chr17:35345994-35345995(+) m6A CDS       26404942 chr17:35346009-35346010(+) m6A CDS       26404942 chr17:35414029-35414030(+) m6A 3'UTR//exon       - chr17:35414089-35414090(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hiv1-miR-H1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	AATF	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-H1
Interactor2: AATF

Evidence Support:

Strong-Evidence	RT-PCR//Western blot
Support Database	ViRBase

References:

[1]PMID	19082544	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Human blood mononuclear cells	Interactor2 expression	Downregulation
Description	The results of these experiments revealed that: (a) HIV-1 genome-encoded matured miRNA was able to suppress selectively and specifically cellular AATF protein expression by about 80% as compared to the corresponding control (Fig.1).

[2]PMID	21133815	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Human blood mononuclear cells	Interactor2 expression	Downregulation
Description	MiR-H1 has been demonstrated to degrade the apoptosis antagonizing transcription factor (AATF) gene product[41].

[3]PMID	22936931	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Human blood mononuclear cells	Interactor2 expression	Downregulation
Description	Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators.