Detail Information

Basic Information:


  VIRBase ID:  

VHID00689245

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-H1:           MYC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hiv1-miR-H1 MYC
miRBase
Accession/Entrez ID		 MIMAT0004480 4609
Organism Human immunodeficiency virus 1 (HIV-1) Homo sapiens
Category miRNA mRNA
Alias - bHLHe39//c-Myc//MRTL//MYCC

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MYC
chr8:128752212(+) C-T intron -    22484847
chr8:128752228(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYC
chr8:128747856-128747857(+) m6A 5'UTR       24284625
chr8:128747998-128747999(+) m6A 5'UTR       24284625
chr8:128748018-128748019(+) m6A 5'UTR       24284625
chr8:128748315-128748316(+) m6A 5'UTR//intron       24284625//24981863
chr8:128748596-128748597(+) Y 5'UTR//intron       26075521
chr8:128748673-128748674(+) m6A 5'UTR//intron       24284625//24981863//26404942//22575960
chr8:128748711-128748712(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748776-128748777(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748798-128748799(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748864-128748865(+) m6A 5'UTR//CDS       24284625//24981863//22575960
chr8:128750539-128750540(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22575960
chr8:128750596-128750597(+) m6A CDS       24284625//24981863//26404942//22575960
chr8:128750761-128750762(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750833-128750834(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750842-128750843(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750874-128750875(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750887-128750888(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750902-128750903(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750980-128750981(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128750995-128750996(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128751142-128751143(+) m6A CDS       24284625//22575960
chr8:128751237-128751238(+) m6A CDS       24284625//22575960
chr8:128752648-128752649(+) m6A CDS       24284625//22575960
chr8:128752750-128752751(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr8:128752836-128752837(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752866-128752867(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752885-128752886(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752886-128752887(+) Cm CDS       -
chr8:128752929-128752930(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752955-128752956(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753040-128753041(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753136-128753137(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753158-128753159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753167-128753168(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753173-128753174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753179-128753180(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753190-128753191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753261-128753262(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753316-128753317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753341-128753342(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753356-128753357(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:128753373-128753374(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hiv1-miR-H1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
MYC
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hiv1-miR-H1
Interactor2: MYC

Evidence Support:


Strong-Evidence RT-PCR//Western blot
Support Database ViRBase

References:


[1]PMID 19082544 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Human blood mononuclear cells Interactor2 expression Downregulation
Description This cellular AATF gene knockdown was accompanied by significant downregulation of genes coding for c-myc, Bcl-2, beta-amyloid at the translational level as well as about ninefold suppression of genes coding for Par-4 and Dicer at the transcriptional level (Figs.1,3b) with respect to their corresponding controls.
[2]PMID 22936931 Target region None
Source ViRBase Interactor1 expression None
Tissue or cell line Human blood mononuclear cells Interactor2 expression Downregulation
Description Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators.

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