Basic Information:

  VIRBase ID:  

VHID00687905

  Virus:  

Human immunodeficiency virus 1 (HIV-1)

  Host:  

Homo sapiens

  Confidence Score:  

0.9105

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hiv1-miR-H1:  MIMAT0004480          hsa-mir-149:  MI0000478     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hiv1-miR-H1	hsa-mir-149
miRBase Accession/Entrez ID	MIMAT0004480	MI0000478
Organism	Human immunodeficiency virus 1 (HIV-1)	Homo sapiens
Category	miRNA	miRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-mir-149	rs1035742243 chr2:240456004    G/A rs1040801427 chr2:240456010    C/G rs1040801427 chr2:240456010    C/T rs1236334592 chr2:240456084    G/A rs1279054554 chr2:240456007    GC/G rs1284538933 chr2:240456081    G/A rs1341642538 chr2:240456008    C/T rs1349217248 chr2:240456001    G/A rs1353517977 chr2:240456077    TG/T rs1378389321 chr2:240456087    G/A rs1378389321 chr2:240456087    G/T rs1436952205 chr2:240456002    C/T rs1444693822 chr2:240456085    C/A rs1444693822 chr2:240456085    C/T rs1488152983 chr2:240456046    C/T rs2292832 chr2:240456086    T/A rs2292832 chr2:240456086    T/C rs529866043 chr2:240456003    C/T rs545070597 chr2:240456038    G/A rs71428439 chr2:240456083    A/G rs762457734 chr2:240456049    AGGAG/A rs771452552 chr2:240456078    G/A rs771452552 chr2:240456078    G/T rs776925770 chr2:240456082    C/A rs889084835 chr2:240456006    C/G rs889084835 chr2:240456006    C/T rs909108369 chr2:240456048    G/A rs933053137 chr2:240456089    A/C rs950715248 chr2:240456011    G/A rs983871621 chr2:240456047    C/A rs983871621 chr2:240456047    C/T rs1405842421 chr2:240456062    G/A rs1412989618 chr2:240456061    G/C rs1412989618 chr2:240456061    G/T rs747327479 chr2:240456058    G/C

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hiv1-miR-H1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	hsa-mir-149	Cytoplasm HeLa cells     22058130 Exosome Epidermal melanocytes (HEMa-LP)|Malignant melanoma cell line (A375)     23056502 Nucleus HeLa cells     22058130

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID	Function
ncDR	hsa-mir-149	Gemcitabine 60750 Drug resistant Temozolomide 5394 Drug sensitive Bortezomib 387447 Drug resistant Paclitaxel 36314 Drug sensitive Paclitaxel 36314 Drug sensitive 5-Fluorouracil 3385 Drug resistant Doxorubicin 31703 Drug resistant Doxorubicin 31703 Drug resistant Doxorubicin 31703 Drug sensitive Doxorubicin 31703 Drug sensitive cis-Diaminedichloroplatinum 2767 Drug resistant cis-Diaminedichloroplatinum 2767 Drug resistant Tamoxifen 2733526 Drug resistant Docetaxel 148124 Drug resistant Docetaxel 148124 Drug sensitive Methotrexate 126941 Drug resistant

Resource	Symbol	Drug Name	PubChem ID	PMID
NoncoRNA	hsa-mir-149	Cisplatin 5702198       29441968 Temozolomide 5394       25017996 Paclitaxel 36314       25156775 Paclitaxel 36314       26223974 Paclitaxel 36314       29261027 5-Fluorouracil 3385       25156775 5-Fluorouracil 3385       27415661 Doxorubicin 31703       25156775

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	hsa-mir-149	Carbamodithioic acid, dimethyl-, 2,4-dinitrophenyl ester       6967 N,N-Diethyl-4-nitrosoaniline       67115 Pepstatin       5478883 2-[(3S,4S,6R)-4,6-Diethyl-6-[(2E,5E)-4-ethylocta-2,5-dienyl]dioxan-3-yl]acetic acid       5472497 21-[2-(N,3,5(10),17(20)-Tetraen-3-ol citrate salt       54612678 1-(2,5-Dimethoxyphenyl)-2-nitropropene       5376407 2-Methoxy-4-[(1Z)-2-nitroprop-1-en-1-yl]phenol       5354204 N-(5-Ethylsulfonyl-2-methoxyphenyl)-5-(3-fluorophenyl)-1,3-oxazol-2-amine       5329861 Ptilomycalin A format salt       395755 3-[(7-Methoxy-1-nitroacridin-9-yl)amino]propan-1-ol       384251 Tamoxifen       2733526 9H-Purin-2-amine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9-(2-methylpropyl)-       239491 2-Methoxyphenazine, 5,10-dioxide       228616 {4-[5-(4-Fluoro-phenyl)-3-(1-methyl-piperidin-4-yl)-3H-imidazol-4-yl]-pyrimidin-2-yl}-phenyl-amine       17892742 Silver benzoate       164649 5-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one       135580426 Butylcycloheptylprodiginine hydrochloride       135539743 4-Piperidinopyrazolo[3,4-d]pyrimidin-6-thion       135436397 1-Bromo-2,4-dinitrobenzene       11441 ;1-(4-methoxyphenyl)-3-(6-methyl-1H-benzo[d]imidazol-2-y...       - 5,5''-dihydroxymethyl-2,2',5',2''-terfuran       - 6h-purine-6-thione, 2-amino-1,9-dihydro-, gold complex       - 8,9-dimethyl-pyrido[2,3-e]isoindolo[1,2-a]pyrazin-6(5h)one       - ;(E)-3-((2-phenylimidazo[1,2-a]pyridin-3-yl)methylene)in...       - michicarcin       - ;N1-(1,3-benzothiazol-6-yl)-2-(4-(2-(1,3-dioxo-2,3-dihyd...       - naphthalen-1,4-dione, 3-butanoylamino-2-chloro-1,4-dihydro-       - ;(R)-2-[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperi...       - ;(S)-2-[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperi...       -

Interaction Network (The top 100 interactions):

Interactor1: hiv1-miR-H1
Interactor2: hsa-mir-149

Evidence Support:

Strong-Evidence	qPCR//RT-PCR
Prediction-Evidence	cRep//miRanda//PITA//RNA22//RNAHybrid//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

[1]PMID	19082544	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	Human blood mononuclear cells	Interactor2 expression	Downregulation
Description	However, the observed pronounced downregulation effect of hiv1-mir-H1 on mir149 expression may be due to its ability to target this miRNA (Fig.5) rather than through the downregulation of Dicer gene.

[2]PMID	22936931	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	Human blood mononuclear cells	Interactor2 expression	Downregulation
Description	Table 1 includes the RNAi pathway related gene products that are targeted by HIV-1 microRNAs. List of published HIV-1 microRNAs and their target HIV-1 and cellular gene products.The target interactions of HIV-1 microRNAs with its mRNA seem to function as viral genome regulators.