Basic Information:

  VIRBase ID:  

VHID00651171

  Virus:  

Suid alphaherpesvirus 1 (Pseudorabies virus JS-2012 strain)

  Host:  

Sus scrofa

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      prv-miR-LLT10b:  MIMAT0025314          SMAD2:  NM_001256148     

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Interactor Information:

	Interactor1	Interactor2
Symbol	prv-miR-LLT10b	SMAD2
miRBase Accession/Entrez ID	MIMAT0025314	100155304
Organism	Suid alphaherpesvirus 1 (Pseudorabies virus JS-2012 strain)	Sus scrofa
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD2	chr1:106901519-106901520(-) m6A CDS       28267806 chr1:106901536-106901537(-) m6A CDS       28267806 chr1:106901551-106901552(-) m6A CDS       28267806 chr1:106901580-106901581(-) m6A CDS       28267806 chr1:106964405-106964406(-) m6A CDS       28267806 chr1:106964463-106964464(-) m6A CDS       28267806 chr1:106964526-106964527(-) m6A CDS       28267806 chr1:106964569-106964570(-) m6A 5'UTR       28267806 chr1:106964588-106964589(-) m6A 5'UTR       28267806 chr1:106991001-106991002(-) m6A 5'UTR       28267806 chr1:106991024-106991025(-) m6A 5'UTR       28267806 chr1:106991038-106991039(-) m6A 5'UTR       28267806 chr1:106991066-106991067(-) m6A 5'UTR       28267806

Interaction Network (The top 100 interactions):

Interactor1: prv-miR-LLT10b
Interactor2: SMAD2

Evidence Support:

Weak-Evidence	Small RNA sequencing
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase

References:

PMID	26998839	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	PK15 cells	Interactor2 expression	None
Description	A total of 36 miRNAs, including 11 known miRNAs and 25 novel miRNAs, were mapped to the PRV JS-2012 genome. We used RNAhybrid and miRanda software to scan the potential viral gene targets for these miRNAs. We scanned the 3'UTRs of PRV-encoded genes, including the LLT and found that each gene can be targeted by one or more miRNAs.