Basic Information:

  VIRBase ID:  

VHID00604492

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.9630

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      mcmv-miR-M23-2-3p:  MIMAT0005545          Cxcl16:  NM_023158     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mcmv-miR-M23-2-3p	Cxcl16
miRBase Accession/Entrez ID	MIMAT0005545	66102
Organism	Murid betaherpesvirus 1	Mus musculus
Category	miRNA	mRNA
Alias	-	0910001K24Rik//AV290116//b2b498C//b2b498Clo//BB024863//CXCL16v1//CXCL16v2//SR//SR-PSOX//Zmynd15

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Cxcl16	chr11:70454030-70454031(-) m6A 3'UTR       24981863 chr11:70454073-70454074(-) m6A 3'UTR       24981863 chr11:70454101-70454102(-) m6A 3'UTR       24981863 chr11:70454146-70454147(-) m6A 3'UTR       24981863 chr11:70454156-70454157(-) m6A 3'UTR       24981863 chr11:70455200-70455201(-) m6A 3'UTR//exon       24981863 chr11:70455261-70455262(-) m6A 3'UTR//exon       24981863 chr11:70455279-70455280(-) m6A 3'UTR//exon       24981863 chr11:70455896-70455897(-) m6A CDS//exon       25683224//24981863 chr11:70455965-70455966(-) m6A CDS//exon       25683224//24981863 chr11:70455975-70455976(-) m6A CDS//exon       25683224//24981863 chr11:70455996-70455997(-) m6A CDS//exon       24981863 chr11:70456021-70456022(-) m6A CDS//exon       24981863 chr11:70456053-70456054(-) m6A CDS//exon       24981863 chr11:70459538-70459539(-) m6A 5'UTR//exon       24981863//25412662 chr11:70459605-70459606(-) m6A 5'UTR//exon       24981863//25412662 chr11:70459622-70459623(-) m6A 5'UTR//exon       24981863//25412662 chr11:70459720-70459721(-) m6A 5'UTR//exon       24981863//25569111 chr11:70459820-70459821(-) m6A 5'UTR//exon       25683224//25456834//24981863//25569111 chr11:70459844-70459845(-) m6A 5'UTR       25683224//25456834//24981863//25569111 chr11:70459882-70459883(-) m6A 5'UTR       25683224//25456834//24981863//25569111 chr11:70459890-70459891(-) m6A 5'UTR       25683224//25456834//24981863//25569111 chr11:70459961-70459962(-) m6A 5'UTR       25683224//25456834//24981863//25569111

Interaction Network (The top 100 interactions):

Interactor1: mcmv-miR-M23-2-3p
Interactor2: Cxcl16

Evidence Support:

Strong-Evidence	Dual luciferase reporter assay//Northern blot//qPCR
Prediction-Evidence	cRep//Rep
Support Database	RepTar//ViRBase//VmiReg

References:

[1]PMID	20976200	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	NIH-3T3 cells	Interactor2 expression	Downregulation
Description	Using 2'-O-methylated antisense oligonucleotide, we confirmed that the CXCL16 reporter regulation by miR-M23-2 could be inhibited in a sequence specific manner.

[2]PMID	21277611	Target region	3'UTR
Source	RepTar//ViRBase	Interactor1 expression	None
Tissue or cell line	NIH-3T3 cells	Interactor2 expression	Downregulation
Description	While the molecular basis of the escape remains to be unraveled (the chemokine CXCL16 was identified as a putative target of miR-M23-2, but is unlikely to be solely responsible for the phenotype), the study by Dlken and colleagues demonstrates the power of investigating miRNAs functions in the context of an authentic in vivo infection. It is unlikely that the phenotype would have been noticed by any other approach.