Basic Information: VIRBase ID: VHID00585341 Virus: Macacine gammaherpesvirus 4 Host: Macaca mulatta Confidence Score: 0.9797 Interaction Type: Virus-Host interaction Predicted Binding:
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Interaction Network (The top 100 interactions) :
Interactor1: rlcv-miR-rL1-8-5p
Interactor2: NFKB1
Evidence Support:
Strong-Evidence
Dual luciferase reporter assay//qRT-PCR//Western blot
Weak-Evidence
RIP-seq//Small RNA sequencing
Support Database
ViRBase
References:
PMID
24257599 Target region
None
Source
ViRBase
Interactor1 expression
None
Tissue or cell line
Rhesus macaque LCLs
Interactor2 expression
Downregulation
Description
These data demonstrate that miR-rL1-8 can functionally substitute for miR-BART5 and that miR-BART5 and miR-BART16 negatively regulate NF-kappaB signaling by directly targeting the LMP1 3'UTR.
