Detail Information

Basic Information:


  VIRBase ID:  

VHID00518727

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           PLIN5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p PLIN5
miRBase
Accession/Entrez ID		 MIMAT0001581 440503
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - LSDA5//LSDP5//MLDP//OXPAT

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLIN5
chr19:4526787(-) A-I      intronic
chr19:4527729(-) A-I      intronic
chr19:4527735(-) A-I      intronic
chr19:4528019(-) A-I      intronic
chr19:4526471(-) A-I      intronic
chr19:4527757(-) A-I      intronic
chr19:4526810(-) A-I      intronic
chr19:4526447(-) A-I      intronic
chr19:4526800(-) A-I      intronic
chr19:4526801(-) A-I      intronic
chr19:4526489(-) A-I      intronic
chr19:4528105(-) A-I      intronic
chr19:4528116(-) A-I      intronic
chr19:4528126(-) A-I      intronic
chr19:4528150(-) A-I      intronic
chr19:4528171(-) A-I      intronic
chr19:4526636(-) A-I      intronic
chr19:4527770(-) A-I      intronic
chr19:4526696(-) A-I      intronic
chr19:4526707(-) A-I      intronic
chr19:4526715(-) A-I      intronic
chr19:4526250(-) A-I      intronic
chr19:4526269(-) A-I      intronic
chr19:4526281(-) A-I      intronic
chr19:4526306(-) A-I      intronic
chr19:4526310(-) A-I      intronic
chr19:4526319(-) A-I      intronic
chr19:4526339(-) A-I      intronic
chr19:4528090(-) A-I      intronic
chr19:4527775(-) A-I      intronic
chr19:4527795(-) A-I      intronic
chr19:4527989(-) A-I      intronic
chr19:4528027(-) A-I      intronic
chr19:4526437(-) A-I      intronic
chr19:4526480(-) A-I      intronic
chr19:4526484(-) A-I      intronic
chr19:4526504(-) A-I      intronic
chr19:4526505(-) A-I      intronic
chr19:4526528(-) A-I      intronic
chr19:4526623(-) A-I      intronic
chr19:4526770(-) A-I      intronic
chr19:4527032(-) A-I      intronic
chr19:4528046(-) A-I      intronic
chr19:4528050(-) A-I      intronic
chr19:4528060(-) A-I      intronic
chr19:4527185(-) A-I      intronic
chr19:4527045(-) A-I      intronic
chr19:4527081(-) A-I      intronic
chr19:4527123(-) A-I      intronic
chr19:4528086(-) A-I      intronic
chr19:4527177(-) A-I      intronic
chr19:4527184(-) A-I      intronic
chr19:4527193(-) A-I      intronic
chr19:4528089(-) A-I      intronic
chr19:4528091(-) A-I      intronic
chr19:4528092(-) A-I      intronic
chr19:4528093(-) A-I      intronic
chr19:4528096(-) A-I      intronic
chr19:4528099(-) A-I      intronic
chr19:4527164(-) A-I      intronic
chr19:4527209(-) A-I      intronic
chr19:4527212(-) A-I      intronic
chr19:4527264(-) A-I      intronic
chr19:4527589(-) A-I      intronic
chr19:4527626(-) A-I      intronic
chr19:4527725(-) A-I      intronic
chr19:4527733(-) A-I      intronic
chr19:4527745(-) A-I      intronic
chr19:4527748(-) A-I      intronic
chr19:4527749(-) A-I      intronic
chr19:4522792(-) A-I      3'UTR
chr19:4522811(-) A-I      3'UTR
chr19:4522839(-) A-I      3'UTR
chr19:4522810(-) A-I      3'UTR
chr19:4527831(-) A-I      intronic
chr19:4524307(-) A-I      intronic
chr19:4527468(-) A-I      intronic
chr19:4527061(-) A-I      intronic
chr19:4526276(-) A-I      intronic
chr19:4526690(-) A-I      intronic
chr19:4527657(-) A-I      intronic
chr19:4526512(-) A-I      intronic
chr19:4526813(-) A-I      intronic
chr19:4527419(-) A-I      intronic
chr19:4526514(-) A-I      intronic
chr19:4526783(-) A-I      intronic
chr19:4527709(-) A-I      intronic
chr19:4526357(-) A-I      intronic
chr19:4527357(-) A-I      intronic
chr19:4526358(-) A-I      intronic
chr19:4527356(-) A-I      intronic
chr19:4527694(-) A-I      intronic
chr19:4526675(-) A-I      intronic
chr19:4527625(-) A-I      intronic
chr19:4527708(-) A-I      intronic
chr19:4526844(-) A-I      intronic
chr19:4526610(-) A-I      intronic
chr19:4526758(-) A-I      intronic
chr19:4527429(-) A-I      intronic
chr19:4526692(-) A-I      intronic
chr19:4527857(-) A-I      intronic
chr19:4527774(-) A-I      intronic
chr19:4527265(-) A-I      intronic
chr19:4528194(-) A-I      intronic
chr19:4527220(-) A-I      intronic
chr19:4526506(-) A-I      intronic
chr19:4527451(-) A-I      intronic
chr19:4527006(-) A-I      intronic
chr19:4527125(-) A-I      intronic
chr19:4527717(-) A-I      intronic
chr19:4526596(-) A-I      intronic
chr19:4528018(-) A-I      intronic
chr19:4526814(-) A-I      intronic
chr19:4522787(-) A-I      3'UTR
chr19:4526762(-) A-I      intronic
chr19:4526492(-) A-I      intronic
chr19:4526788(-) A-I      intronic
chr19:4527850(-) A-I      intronic
chr19:4527226(-) A-I      intronic
chr19:4526667(-) A-I      intronic
chr19:4524426(-) A-I      intronic
chr19:4527612(-) A-I      intronic
chr19:4527489(-) A-I      intronic
chr19:4527624(-) A-I      intronic
chr19:4527537(-) A-I      intronic
chr19:4526331(-) A-I      intronic
chr19:4527258(-) A-I      intronic
chr19:4526793(-) A-I      intronic
chr19:4527256(-) A-I      intronic
chr19:4528193(-) A-I      intronic
chr19:4526427(-) A-I      intronic
chr19:4527216(-) A-I      intronic
chr19:4527520(-) A-I      intronic
chr19:4524398(-) A-I      intronic
chr19:4527004(-) A-I      intronic
chr19:4527944(-) A-I      intronic
chr19:4527609(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PLIN5
chr19:4528523(-) A-I intron -    15342557
chr19:4528549(-) A-I intron -    15342557
chr19:4528585(-) A-I intron -    15342557
chr19:4528592(-) A-I intron -    15342557
chr19:4529551(-) A-I intron -    15342557
chr19:4529674(-) A-I intron -    15342557

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLIN5
chr19:4522656-4522657(-) m6A 3'UTR       -
chr19:4522679-4522680(-) m6A 3'UTR       -
chr19:4522721-4522722(-) m6A 3'UTR       -
chr19:4522799-4522800(-) m6A 3'UTR       -
chr19:4522951-4522952(-) m6A 3'UTR       -
chr19:4523022-4523023(-) m6A 3'UTR       -
chr19:4523129-4523130(-) m6A 3'UTR       -
chr19:4523326-4523327(-) m6A 3'UTR       -
chr19:4523356-4523357(-) m6A 3'UTR       -
chr19:4523364-4523365(-) m6A 3'UTR       -
chr19:4523385-4523386(-) m6A 3'UTR       -
chr19:4523546-4523547(-) m6A CDS       24284625//25456834//27773536//22608085
chr19:4523589-4523590(-) m6A CDS       24284625//25456834//27773536//22608085
chr19:4523596-4523597(-) m6A CDS       24284625//25456834//27773536//22608085
chr19:4523612-4523613(-) m6A CDS       24284625//25456834//27773536//22608085
chr19:4523633-4523634(-) m6A CDS       24284625//25456834//27773536//22608085
chr19:4523699-4523700(-) m6A CDS       25456834//27773536//22608085
chr19:4523750-4523751(-) m6A CDS       25456834//27773536//22608085
chr19:4523803-4523804(-) m6A CDS       25456834//27773536
chr19:4523949-4523950(-) m6A CDS//exon       -
chr19:4525083-4525084(-) m6A CDS//exon       -
chr19:4525678-4525679(-) m6A CDS//exon       -
chr19:4525692-4525693(-) m6A CDS//exon       -
chr19:4525707-4525708(-) m6A CDS//exon       -
chr19:4525785-4525786(-) m6A CDS//exon       -
chr19:4529003-4529004(-) m6A intron       -
chr19:4529212-4529213(-) m6A CDS       -
chr19:4534075-4534076(-) m1A CDS//exon       26863196

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PLIN5
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: PLIN5

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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