Detail Information

Basic Information:


  VIRBase ID:  

VHID00518589

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SNX19:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SNX19
miRBase
Accession/Entrez ID		 MIMAT0001581 399979
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CHET8

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SNX19
chr11:130754684(-) A-I      intronic
chr11:130761910(-) A-I      intronic
chr11:130761846(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SNX19
chr11:130751481(-) A-I intron -    21960545

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SNX19
chr11:130746346-130746347(-) m6A 3'UTR       27773535
chr11:130746410-130746411(-) m6A 3'UTR       27773535
chr11:130747206-130747207(-) Tm 3'UTR       -
chr11:130747344-130747345(-) m6A 3'UTR       24981863
chr11:130747394-130747395(-) m6A 3'UTR       24981863//27773535
chr11:130747484-130747485(-) m6A 3'UTR       27773535
chr11:130747650-130747651(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr11:130747747-130747748(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747815-130747816(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747820-130747821(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828
chr11:130747851-130747852(-) m6A 3'UTR//exon       24284625//25456834//24981863//27773535//27371828//22608085
chr11:130747884-130747885(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130747913-130747914(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130747924-130747925(-) m6A 3'UTR//exon       24284625//24981863//27773535//27371828//22608085
chr11:130748029-130748030(-) m6A 3'UTR//exon       24284625
chr11:130750953-130750954(-) m6A exon//intron       -
chr11:130762855-130762856(-) m6A exon//intron       27773535
chr11:130775634-130775635(-) m6A 3'UTR//intron       24981863
chr11:130775645-130775646(-) m6A 3'UTR//intron       24981863
chr11:130775867-130775868(-) m6A CDS//exon       24981863
chr11:130775903-130775904(-) m6A CDS//exon       24981863//27773535
chr11:130775926-130775927(-) m6A CDS//exon       27773535
chr11:130775980-130775981(-) m6A CDS//exon//intron       27773535
chr11:130776018-130776019(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130776553-130776554(-) m6A 5'UTR//CDS//exon       27773535
chr11:130777887-130777888(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777924-130777925(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777944-130777945(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130777955-130777956(-) m6A 5'UTR//CDS//exon//intron       27773535
chr11:130781640-130781641(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr11:130781659-130781660(-) m6A 5'UTR//CDS//exon       24981863//27773535
chr11:130784239-130784240(-) m6A CDS//intron       24284625//24981863//27773535
chr11:130784411-130784412(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:130784463-130784464(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784476-130784477(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784534-130784535(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784540-130784541(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784546-130784547(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784598-130784599(-) m6A 5'UTR//CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:130784684-130784685(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536//22575960//22608085
chr11:130784697-130784698(-) m6A CDS//intron       24284625//25456834//24981863//27371828//27773536
chr11:130784725-130784726(-) m6A CDS//intron       24284625//24981863
chr11:130784782-130784783(-) m6A CDS//intron       24284625//24981863
chr11:130784985-130784986(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:130785114-130785115(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:130785143-130785144(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:130785385-130785386(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr11:130785800-130785801(-) m6A CDS//intron       24284625
chr11:130785821-130785822(-) m6A CDS//intron       24284625
chr11:130785827-130785828(-) m6A CDS//intron       24284625
chr11:130785916-130785917(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130785944-130785945(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130785975-130785976(-) m6A 5'UTR//intron       24284625//24981863//27371828//22575960
chr11:130786269-130786270(-) m6A 5'UTR//exon       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SNX19
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SNX19

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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