Detail Information

Basic Information:


  VIRBase ID:  

VHID00518418

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           VGLL3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p VGLL3
miRBase
Accession/Entrez ID		 MIMAT0001581 389136
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - VGL-3//VGL3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VGLL3
chr3:87023442(-) A-I      intronic
chr3:87023379(-) A-I      intronic
chr3:87023439(-) A-I      intronic
chr3:87023472(-) A-I      intronic
chr3:87023482(-) A-I      intronic
chr3:87023392(-) A-I      intronic
chr3:87023457(-) A-I      intronic
chr3:87004568(-) A-I      intronic
chr3:87023432(-) A-I      intronic
chr3:87023428(-) A-I      intronic
chr3:87023423(-) A-I      intronic
chr3:87023364(-) A-I      intronic
chr3:87023446(-) A-I      intronic
chr3:87023496(-) A-I      intronic
chr3:87023365(-) A-I      intronic
chr3:87023396(-) A-I      intronic
chr3:87023373(-) A-I      intronic
chr3:86988583(-) A-I      3'UTR
chr3:86988609(-) A-I      3'UTR
chr3:87023477(-) A-I      intronic
chr3:86993598(-) A-I      3'UTR
chr3:87011911(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VGLL3
chr3:86987686-86987687(-) m6A 3'UTR       24981863//22575960//22608085
chr3:86987724-86987725(-) m6A 3'UTR       24981863//22575960//22608085
chr3:86987785-86987786(-) m6A 3'UTR       22575960//22608085
chr3:86987797-86987798(-) m6A 3'UTR       22575960//22608085
chr3:86995998-86995999(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996059-86996060(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996083-86996084(-) m6A 3'UTR       24209618//25456834//24981863//26404942//22575960//22608085
chr3:86996171-86996172(-) m6A 3'UTR       24209618//24981863//26404942//22575960//22608085
chr3:86996201-86996202(-) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr3:87017768-87017769(-) m6A CDS       24209618//24981863//22575960
chr3:87017775-87017776(-) m6A CDS       24209618//24981863//22575960
chr3:87017827-87017828(-) m6A CDS       24209618//24981863//22575960
chr3:87017832-87017833(-) m6A CDS       24209618//24981863//22575960
chr3:87018093-87018094(-) m6A CDS       24284625//24209618//24981863//22575960
chr3:87018109-87018110(-) m6A CDS       24284625//24209618//25456834//24981863//22575960
chr3:87018154-87018155(-) m6A CDS       24209618//24981863//22575960
chr3:87018222-87018223(-) m6A CDS       24209618//22575960
chr3:87027766-87027767(-) m6A CDS       24209618//25456834//24981863//22575960
chr3:87027788-87027789(-) m6A CDS       24209618//25456834//24981863//22575960
chr3:87027851-87027852(-) m6A CDS//intron       25456834//24981863//22575960
chr3:87027892-87027893(-) m6A CDS//intron       25456834
chr3:87027920-87027921(-) m6A CDS//intron       22575960
chr3:87040024-87040025(-) m6A 5'UTR       22575960
chr3:87040126-87040127(-) m6A 5'UTR       22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate VGLL3
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: VGLL3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...